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1. 2021-01-23 17:49 Robert F. Garry open
   Andrew alluded to it and I agree it's true - some spots on the genome are "slippery" or prone to mutation. It's the variable and constant domain meme of HIV, fle etc. In one sense hopeful since it suggests that while the space for mutation/adaptation is large it's not infinite. As @Andrew Rambaut referenced a handful ofimmunosuppressed/cancer patients out there (two NEJM paper) with patients with overlapping or common mutation/deletions, a few of which actually flip back and forth in the "quasispecies.' The strongly immunosuppressed/persistent patients interesting - KGA aware of one of ours at Tulane that has stayed PCR positive for over 8 months. No provirus and a rudimentary proofing mechanism but still as Emma Hodcraft said aplayground for the virus.
2. 2021-01-23 17:49 Andrew Rambaut open
   Got to go to bed and stop staring at mutations.
3. 2021-01-23 17:54 Robert F. Garry open
   Yes but I really don't want to think about the blissfully ignorant mess we'd be in if YOU hadn't been staring atmutations over the past several months.
4. 2021-01-23 17:55 Edward C. Holmes open
   Bob, you used the Q word.
5. 2021-01-23 18:00 Kristian G. Andersen
   Oh oh.
6. 2021-01-23 18:02 Edward C. Holmes open
   Spent HOURS putting the GIPA together...kind of hoping that the 'grand wizard of EgoHealth' makes into the public domain
7. 2021-01-23 18:02 Kristian G. Andersen open
   That'd be fun.
8. 2021-01-23 18:03 Kristian G. Andersen open
   Key question here - in an area of high standing immunity or low?
9. 2021-01-23 18:38 Robert F. Garry open
   @Eddie Holmes moment of weakness :scream_cat:

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