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Slack / Private Message Drop, p.397 [SLACK_000611] · slack_pm:msg:04097

Page text: p.397 · original PDF

Date
2021-01-14 13:11
Type
chat message · slack
recipient
Kristian G. Andersen, Robert F. Garry, Edward C. Holmes
speaker
Andrew Rambaut
Topics
Intelligence community assessments

Recipients on this medium are inferred from channel membership, not per-message addressing.

Jeez: ```We report the presence of a viral isolate from late December 2020 in Columbus Ohio that has acquired the S N501Y variant. This amino acid change was first described in a clinical sample in the United Kingdom in association with other novel S variants and a clade 20B backbone (ECDC, 2020; Davies et al, 2020), with the combination named as the B.1.1.7 strain and a Next Strain designation as 20I/501Y.V1 (Bedford et al, 2021). The same N501Ymutation was subsequently found in a clade 20C strain in South Africa, where it was associated with a different setof additional S variants (Tegally et al, 2020), with Next Strain designation as 20H/501Y.V3. ```What a fucking mess Trevor has created. "It has acquired the N501Y variant".

Extracted statements

Rule-extracted, not adjudicated. The grade says what may be done with each one; read the document above before relying on any of them.

StatementGradeAttributionStance
This amino acid change was first described in a clinical sample in the United Kingdom in association with other novel S variants and a clade 20B backbone (ECDC, 2020; Davies et al, 2020), with the combination named as the B.1.1.7 strain and a Next Strain designation as 20I/501Y.V1 (Bedford et al, 2021). own voice, substantive speaker_own asserts
The same N501Ymutation was subsequently found in a clade 20C strain in South Africa, where it was associated with a different setof additional S variants (Tegally et al, 2020), with Next Strain designation as 20H/501Y.V3. ```What a fucking mess Trevor has created. own voice, substantive speaker_own asserts

In context

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  1. 2021-01-14 13:11 Andrew Rambaut
    Jeez: ```We report the presence of a viral isolate from late December 2020 in Columbus Ohio that has acquired the S N501Y variant. This amino acid change was first described in a clinical sample in the United Kingdom in association with other novel S variants and a clade 20B backbone (ECDC, 2020; Davies et al, 2020), with the combination named as the B.1.1.7 strain and a Next Strain designation as 20I/501Y.V1 (Bedford et al, 2021). The same N501Ymutation was subsequently found in a clade 20C strain in South Africa, where it was associated with a different setof additional S variants (Tegally et al, 2020), with Next Strain designation as 20H/501Y.V3. ```What a fucking mess Trevor has created. "It has acquired the N501Y variant".
  2. 2021-01-14 13:19 Andrew Rambaut open
    On that note, I am sure I read this hypothesis somewhere before: https://twitter.com/trvrb/status/1349774308202094594
  3. 2021-01-14 13:23 Edward C. Holmes open
    Aye on both counts. Fucking Trevor!
  4. 2021-01-14 13:25 Andrew Rambaut open
    That Ohio paper is well out of order. They say - UKnB.1.1.7 (clade 20I/501Y.V1) strain. This is not on - you can'tlabel stuff geographically.
  5. 2021-01-14 13:26 Andrew Rambaut open
    `containing several likely pathogenic but distinct mutations in the Spike (S) gene, particularly N501Y.` - what? 'likelypathogenic'? Garbage

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