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Slack / Private Message Drop, p.388 [SLACK_000602] · slack_pm:msg:04041

Page text: p.388 · original PDF

Date
2021-01-12 14:44
Type
chat message · slack
recipient
Kristian G. Andersen, Robert F. Garry, Edward C. Holmes
speaker
Andrew Rambaut

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Yes.

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  1. 2021-01-12 14:39 Andrew Rambaut open
    Or the closest bats to SC1 (could check this myself of course).
  2. 2021-01-12 14:39 Robert F. Garry open
    Good question - that would be interesting...
  3. 2021-01-12 14:42 Andrew Rambaut open
    It is a bit tricky - my alignment is a bit different (I did a nucleotide alignment)
  4. 2021-01-12 14:44 Robert F. Garry open
    THey are the same in the civet..
  5. 2021-01-12 14:44 Andrew Rambaut
    Yes.
  6. 2021-01-12 14:44 Andrew Rambaut open
    And in some of the bats it looks
  7. 2021-01-12 14:49 Robert F. Garry open
    Yes - lots of possibilities, but it looks like SC2 and RaTG13 spikes mostly diverging from SC1 by insertions - including the obvious PRRA.
  8. 2021-01-12 14:52 Robert F. Garry open
    The insertions not needed so put SC2 under the right situation and it starts to delete. Just like im cell culture the FCS and the QTQTN can be deleted.
  9. 2021-01-12 14:56 Robert F. Garry open
    @Andrew Rambaut yes indeed - may get a somewhat different alignment with the nucleotides but the point remains that these are hotspots for deletions. Mechanism TBD but could be swapping out a shorter sequence with end homologiesy via copy-choice.

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