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Slack / Private Message Drop, p.381 [SLACK_000595] · slack_pm:msg:03967

Page text: p.381 · original PDF

Date
2021-01-11 15:09
Type
chat message · slack
recipient
Kristian G. Andersen, Robert F. Garry, Andrew Rambaut
speaker
Edward C. Holmes

Recipients on this medium are inferred from channel membership, not per-message addressing.

I'm really not sure I believe the chronic theory any more...once may be, but three times? Chronic infections are a tiny fraction of the overall population.

In context

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  1. 2021-01-11 15:08 Andrew Rambaut open
    Just bonkers
  2. 2021-01-11 15:08 Kristian G. Andersen open
    Where did they do the AZN trials again?
  3. 2021-01-11 15:08 Andrew Rambaut open
    Johnson and Johnson in Brazil as well - didn't they suspend it because of mystery illness?
  4. 2021-01-11 15:09 Kristian G. Andersen open
    Yup
  5. 2021-01-11 15:09 Edward C. Holmes
    I'm really not sure I believe the chronic theory any more...once may be, but three times? Chronic infections are a tiny fraction of the overall population.
  6. 2021-01-11 15:10 Kristian G. Andersen open
    Epizootic? Chronic infections? Immune escape? I think all in play.
  7. 2021-01-11 15:11 Kristian G. Andersen open
    > It seems like all of these lineages are converging to the same set of mutations And just to this part - it's strongly suggestive of some very pervasive selections pressure that's in common in all these places. Or, alternatively (but I think less likely) something like this: https://www.cell.com/cell/fulltext/S0092-8674(17)30292-1?_returnURL=https%3A%2F%2Fl[...]vier.com%2Fretrieve%2Fpii%2FS0092867417302921%3Fshowall%3Dtrue
  8. 2021-01-11 15:12 Andrew Rambaut open
    Except that these 3 cases have a shit load of other stuff. Masses of spike mutations (and no synonymous in spike). Orf8 mutations and that nsp6 deletion
  9. 2021-01-11 15:12 Kristian G. Andersen open
    Why're we seeing it now and not earlier? More widespread transmission, vaccines being deployed in some places, more standing immunity. But I do feel something's up here - doesn't seem normal to find so many clearly unrelated lineages ending up with a subset of the same mutations. That's just weird.

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