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Slack / Private Message Drop, p.347 [SLACK_000561] · slack_pm:msg:03649

Date: 2020-12-29 09:24
Type: chat message · slack
recipient: Kristian G. Andersen, Edward C. Holmes, Andrew Rambaut
speaker: Robert F. Garry
Topics: Furin cleavage site and molecular features

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```Denmark cats: 69-70 deletion plus Y454F RBD mutation seen in some mink. Do not know the relationship of the cats - maybe all the same cat or cat house. Cat from Greece V1104L Lion 3 and 4 Y505H RBD mutation, not present in Lion 2. Lion 2 Q616R mutation not seen in Lions 3,4. Lions 3, 4 A626I, Lion 2 A626T```

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2020-12-29 09:23 Robert F. Garry open

More fun with cats.
2020-12-29 09:24 Robert F. Garry

```Denmark cats: 69-70 deletion plus Y454F RBD mutation seen in some mink. Do not know the relationship of the cats - maybe all the same cat or cat house. Cat from Greece V1104L Lion 3 and 4 Y505H RBD mutation, not present in Lion 2. Lion 2 Q616R mutation not seen in Lions 3,4. Lions 3, 4 A626I, Lion 2 A626T```
2020-12-29 09:31 Robert F. Garry open

SC2 mostly makes the jump to house cats with no changes. However there are some interesting RDB mutations in some lions (Y505H) and the cat or cats from Denmark (Y454F). The lions also have mutations associated with Doug,
2020-12-29 09:34 Robert F. Garry open

Alignments: [shared file(s): image.png]
2020-12-29 09:35 Kristian G. Andersen open

Very little onward transmission in cats (presumably), so I wouldn't expect much evolution to happen. Compare thatto a mink farm where the virus gets a chance to spread through a whole population of thousands of animals very quickly.
2020-12-29 10:05 Robert F. Garry open

In uptown NOLA there are a lot of wild/street cats. Hundreds of cats hang out around the French quarter and the wharf. I think similar situations in some other countries as well. Certainly not the same intense situation as a mink farm, but I could see an opportunity for spread amongst the feral cats in NOLa - elsewhere dunno. That being said Iagree that in the Danish cat [looking at the GSAID metadata seems that there is only one - all the same sequence] the 69/70 deletion and Y454F mutations were probably in this cat's human already - just not clear to me if as minoror major species. The alternative is selection after the species jump, but this seems less likely, but maybe that's justmy bias. Lions in a zoo yes no onward transmission except to other lions. Clearly two different sequences in the three lions, which makes me think there might be some selection during the species jump or two independent transmissions. The latter seems less likely. Lions 3 and 4 sharing their virus.

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