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Slack / Private Message Drop, pp.322-323 [SLACK_000536] · slack_pm:msg:03395

Date: 2020-12-18 06:50
Type: chat message · slack
recipient: Kristian G. Andersen, Edward C. Holmes, Andrew Rambaut
speaker: Robert F. Garry
Topics: Furin cleavage site and molecular features

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2. The UK variant is important on many levels, but I believe relates directly to the PO of SC2. I don't fathom themechanisms, [maybe there's a precedent in noros or elsewhere] but it looks like the mutations in RBD and the FCS and elsewhere are "coordinated" in some way. The closest correlate I can think of is when you get a mutation in one part of protein you often get a compensatory mutation in another part of the protein - sometimes thesecompensatory mutations interactin the secondary or tertiary structure, but often not so much.https://pubmed.ncbi.nlm.nih.gov/17507468/ or better here: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1599768/[check out the editor].

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gov https://pubmed.ncbi.nlm.nih.gov/17507468/
gov https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1599768/[check

Extracted statements

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Statement	Grade	Attribution	Stance
I don't fathom themechanisms, [maybe there's a precedent in noros or elsewhere] but it looks like the mutations in RBD and the FCS and elsewhere are "coordinated" in some way.	quoted / not their view	quoted_external sentence carries quotation marks	asserts

Statement

Grade

Attribution

Stance

I don't fathom themechanisms, [maybe there's a precedent in noros or elsewhere] but it looks like the mutations in RBD and the FCS and elsewhere are "coordinated" in some way.

quoted / not their view

quoted_external sentence carries quotation marks

asserts

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2020-12-18 06:38 Robert F. Garry open

Couple of thoughts: 1. Yes - virological post was indeed historic and very important!
2020-12-18 06:50 Robert F. Garry

2. The UK variant is important on many levels, but I believe relates directly to the PO of SC2. I don't fathom themechanisms, [maybe there's a precedent in noros or elsewhere] but it looks like the mutations in RBD and the FCS and elsewhere are "coordinated" in some way. The closest correlate I can think of is when you get a mutation in one part of protein you often get a compensatory mutation in another part of the protein - sometimes thesecompensatory mutations interactin the secondary or tertiary structure, but often not so much.https://pubmed.ncbi.nlm.nih.gov/17507468/ or better here: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1599768/[check out the editor].
2020-12-18 07:01 Robert F. Garry open

3. As for the FOI from the USRTK group, which I believe has its roots in the antiGMO cabal - along with right wingers(Bannon/Yan/FOx news) and the out-of-their-lane amateur detectives/DRASTIC. we are up against a lot of people trying [and failing] to tear us down.
2020-12-18 07:05 Andrew Rambaut open

@Robert Garry 2) - I am now utterly convinced it is transmitting faster (I may still be wrong but all the data is pointing that way - and I am super cautious about these things). I think the RBD + furin site must be a top combination. Possibly the 69-70 & 144 deletions just to tune things a bit.
2020-12-18 07:06 Andrew Rambaut open

But I think it probably got selected for higher infectivity within the chronic patient and then got out and took off.
2020-12-18 07:08 Kristian G. Andersen open

If it's from a chronic patient, probably also highly resistant to neuts. Any early data on that? Anything clinical?

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