Slack / Private Message Drop — page 322

[2020-12-17 12:55:20] [Eddie Holmes] [thread - ID: 2020-12-17 05:15:07] @Robert Garry The French comment afterward talked about my 'enormous influence'. Shucks, I'm blushing. [2020-12-17 17:39:32] [Kristian Andersen] Pretty cool, this. - from https://vis.sciencemag.org/breakthrough2020/#/finalists/a-divisive-disease [shared file(s): Screen Shot 2020-12-17 at 5.39.12 PM.png] [2020-12-17 18:01:21] [Eddie Holmes] It is! [2020-12-17 18:08:06] [Eddie Holmes] One for the history books. [2020-12-18 01:41:56] [Andrew Rambaut] https://twitter.com/sai_suryan/status/1339859716613287937 [2020-12-18 01:42:10] [Andrew Rambaut] I am guessing the reviews will come out in the FOI, Eddie? [2020-12-18 01:42:31] [Andrew Rambaut] ```@k_g_andersen @arambaut @edwardcholmes #IanLipkin #RobertGarry: according to @nature, "correspondence submissions are only rarely peer-reviewed." https://go.nature.com/37w0Crb Was "The proximal origin of SARS-CoV-2" peer-reviewed by experts before its publication? #originsofsarscov2``` [2020-12-18 02:17:20] [Eddie Holmes] I just blocked him. Total low-life. No, I don't we need to show the reviews as these are correspondence with the journal and my University lawyers say that is not included. But it will have us talking about the reviews a guess. Of course, the irony is that the reviewers thought we gave the lab escape theory too much credence...I'm not going to make life easy for them. [2020-12-18 02:19:24] [Eddie Holmes] Just been talking (off the record) to this guy from CNN who has been delving deep into the early outbreak. He's also talked to all the intelligence folk. He's says there's absolutely zero evidence for lab escape. Intelligence agrees. Nothing in the early records from China. [2020-12-18 06:38:22] [Robert Garry] Couple of thoughts: 1. Yes - virological post was indeed historic and very important! [2020-12-18 06:50:39] [Robert Garry] 2. The UK variant is important on many levels, but I believe relates directly to the PO of SC2. I don't fathom the mechanisms, [maybe there's a precedent in noros or elsewhere] but it looks like the mutations in RBD and the FCS and elsewhere are "coordinated" in some way. The closest correlate I can think of is when you get a mutation in one part of protein you often get a compensatory mutation in another part of the protein - sometimes these compensatory mutations interactin the secondary or tertiary structure, but often not so much.