Chat message

Slack / Private Message Drop, p.272 [SLACK_000486] · slack_pm:msg:02837

Date: 2020-11-21 14:49
Type: chat message · slack
recipient: Kristian G. Andersen, Robert F. Garry, Andrew Rambaut
speaker: Edward C. Holmes
Topics: Furin cleavage site and molecular features Natural origin / zoonotic spillover

Recipients on this medium are inferred from channel membership, not per-message addressing.

Yes! That underpins 99% of the conspiracy stuff. So dumb. And how you end up with a pangolin-like RBD with a RaTG13 as a progenitor?

In context

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2020-11-21 14:40 Edward C. Holmes open

Yuri Deigin and the powers of BLAST as an alignment tool. I finally blocked him as it was getting so tedious. Proximal Origins 2....I still wonder if we need to wait for more new data?
2020-11-21 14:43 Andrew Rambaut open

Quite possibly need more to hang it on. But it might be good to bash out some ideas and see where we are.
2020-11-21 14:45 Edward C. Holmes open

Don't disagree that with. I would certainly like to take the opportunity to respond to some of the nonsense written about the pangolin viruses. I'll check with Tommy where we are on this.
2020-11-21 14:47 Andrew Rambaut open

Also the idea that RaTG13 is a 'progenitor'.
2020-11-21 14:49 Edward C. Holmes

Yes! That underpins 99% of the conspiracy stuff. So dumb. And how you end up with a pangolin-like RBD with a RaTG13 as a progenitor?
2020-11-21 14:50 Andrew Rambaut open

And when you have RM2 as well
2020-11-21 14:54 Edward C. Holmes open

Perhaps we should ask Nature Medicine if they up for Proximal Origins II? Given that the 1st one has 5 million accesses they might be up for it. I'll just add notes your doc Andrew.
2020-11-21 14:55 Edward C. Holmes open

I think we can lance the butt lesion for the new version though.
2020-11-21 14:55 Andrew Rambaut open

Definitely no BL this time.