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Slack / Private Message Drop, p.271 [SLACK_000485] · slack_pm:msg:02823

Date: 2020-11-21 09:42
Type: chat message · slack
recipient: Kristian G. Andersen, Edward C. Holmes, Andrew Rambaut
speaker: Robert F. Garry
Topics: Furin cleavage site and molecular features

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This was Yoshi's H5 flu experiment: "After 24 consecutive passages by air sac inoculation, followed by five passages in chicken brain, the avirulent virus became highly pathogenic in chickens, producing a 100% mortality rate. Sequence analysis at the hemmaglutinin cleavage site of the original isolate revealed a typical avirulence typeof sequence, R-E-T-R, which progressed incrementally to a typical virulence type of sequence, R-R-K-K-R, during repeated passages in chickens." That's a lot of ferrets for 29 passaages which aren't cheap, but worth the effort.

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2020-11-21 09:42 Robert F. Garry

This was Yoshi's H5 flu experiment: "After 24 consecutive passages by air sac inoculation, followed by five passages in chicken brain, the avirulent virus became highly pathogenic in chickens, producing a 100% mortality rate. Sequence analysis at the hemmaglutinin cleavage site of the original isolate revealed a typical avirulence typeof sequence, R-E-T-R, which progressed incrementally to a typical virulence type of sequence, R-R-K-K-R, during repeated passages in chickens." That's a lot of ferrets for 29 passaages which aren't cheap, but worth the effort.
2020-11-21 09:48 Kristian G. Andersen open

Denmark has a lot of cheap mink up for sale...
2020-11-21 09:56 Robert F. Garry open

Sad but true - you should suggest they put some to a better use than yet another coat for the likes of Melania, Ivanka et al.
2020-11-21 09:59 Robert F. Garry open

Of course with Donny Jr the latest Trump to get infected that crime family doing it's best at "serial passage."
2020-11-21 10:00 Kristian G. Andersen open

Yeah - it seems like a recent mutation in the virus genome might have selected for stupid.

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