Chat message

Slack / Private Message Drop, p.265 [SLACK_000479] · slack_pm:msg:02777

Date: 2020-11-19 12:23
Type: chat message · slack
recipient: Kristian G. Andersen, Robert F. Garry, Andrew Rambaut
speaker: Edward C. Holmes
Topics: Natural origin / zoonotic spillover

Recipients on this medium are inferred from channel membership, not per-message addressing.

"For almost a year we are asking ourselves does Covid-19 have a reservoir or an intermediary host, we worked so hard, [practicing] One Health, we haven't found anything." "For some other viruses, it's so easy to find the intermediary host." [Mers - dromedary, Ebola - mammals, hedra -horses, nipah - swine, lassa fever - rodent] "Yet we tried so hard and we haven't found anything for Covid-19. That makes me think about in a one health setting, is HIV really from a monkey? We know HIV is so close to SIV, but HIV has never been SIV, they separated -we don't know how long ago. But they separated a long, long time ago. Maybe the Covid-19 virus also separatedfrom a bat virus a long, long time ago. We might not be able to find the intermediate host. We have to rethink our theory or hypothesis about the [inaudible perhaps Gao says - logic] of viruses. People think it's closely related tothose monkeys, but the virus has never been the same. This is why we have more questions than answers on the origins of the Covid-19. For any other virus it's so clear, for the Covid-19 we have so many questions remained. IsCovid-19 so easy to be transmitted through the package of the seafood, long distance package, why is that - wedon't know? This is something new. It's a scientific question." (Webinar, part 62)

Extracted statements

Rule-extracted, not adjudicated. The grade says what may be done with each one; read the document above before relying on any of them.

Statement	Grade	Attribution	Stance
We might not be able to find the intermediate host.	quoted / not their view	quoted_external inside quotation marks	asserts

Statement

Grade

Attribution

Stance

We might not be able to find the intermediate host.

quoted / not their view

quoted_external inside quotation marks

asserts

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2020-11-19 12:02 Edward C. Holmes open

Time to post something on Virological.org?
2020-11-19 12:23 Edward C. Holmes open

This is apparently what George Gao said on his online IUMS lecture:
2020-11-19 12:23 Edward C. Holmes

"For almost a year we are asking ourselves does Covid-19 have a reservoir or an intermediary host, we worked so hard, [practicing] One Health, we haven't found anything." "For some other viruses, it's so easy to find the intermediary host." [Mers - dromedary, Ebola - mammals, hedra -horses, nipah - swine, lassa fever - rodent] "Yet we tried so hard and we haven't found anything for Covid-19. That makes me think about in a one health setting, is HIV really from a monkey? We know HIV is so close to SIV, but HIV has never been SIV, they separated -we don't know how long ago. But they separated a long, long time ago. Maybe the Covid-19 virus also separatedfrom a bat virus a long, long time ago. We might not be able to find the intermediate host. We have to rethink our theory or hypothesis about the [inaudible perhaps Gao says - logic] of viruses. People think it's closely related tothose monkeys, but the virus has never been the same. This is why we have more questions than answers on the origins of the Covid-19. For any other virus it's so clear, for the Covid-19 we have so many questions remained. IsCovid-19 so easy to be transmitted through the package of the seafood, long distance package, why is that - wedon't know? This is something new. It's a scientific question." (Webinar, part 62)
2020-11-19 12:24 Edward C. Holmes open

I think he's loosing it.
2020-11-19 12:58 Robert F. Garry open

Agree - pretty lost - Should point out that the Ebola reservoir is unknown and new reservoirs of Lassa virus still being uncovered. Point taken about HIV - there's quite a gap. The transmission on seafood seems like a fluke to me.
2020-11-19 13:00 Robert F. Garry open

Here's a figure compiling indels at the S1/S2 ans S2' spike junctions of coronaviruses. Indels are the rule not the exception. Yes- virological post.... [shared file(s): image.png]
2020-11-19 13:07 Robert F. Garry open

The pesky predicted O-linked glycan sites, which are otherwise rare [a few notable exceptions], keep popping up atthe spike s1/s2 and s2' junctions.

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