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Slack / Private Message Drop, pp.220-221 [SLACK_000434] · slack_pm:msg:02288

Date: 2020-10-16 14:40
Type: chat message · slack
recipient: Kristian G. Andersen, Robert F. Garry, Andrew Rambaut
speaker: Edward C. Holmes
Topics: Intelligence community assessments

Recipients on this medium are inferred from channel membership, not per-message addressing.

Dear Edwards, It would be appreciated if you would help me with the following questions on viral evolution. I want to work on predicting the next viral crisis, but I don't have a clear picture of my idea on this. Here is the idea: One of the main steps in zoonotic transfer is the ability of an animal virus to enter human respiratory cells. So wecan list all surface proteins of human epithelial cells (in the respiratory tract) and then using molecular docking wepredict (viral) complementary proteins. Viruses with these proteins can potentially enter human cells. By translatingthese proteins into nucleotides, we have a list of potentially dangerous viruses; some of them are not yet evolved. Using modeling we can estimate the required time for evolving these viruses from currently available viruses and finally figure out how far we are from the next viral crisis.1. Is this proposal meaningful scientifically?2. Is it already done?3. Any suggestion and comment on this is appreciated.Sincerely yoursHassan

Extracted statements

Rule-extracted, not adjudicated. The grade says what may be done with each one; read the document above before relying on any of them.

Statement	Grade	Attribution	Stance
Dear Edwards, It would be appreciated if you would help me with the following questions on viral evolution.	quoted / not their view	hypothetical conditional framing	asserts
Any suggestion and comment on this is appreciated.Sincerely yoursHassan	needs context	speaker_own	asserts

Statement

Grade

Attribution

Stance

Dear Edwards, It would be appreciated if you would help me with the following questions on viral evolution.

quoted / not their view

hypothetical conditional framing

asserts

Any suggestion and comment on this is appreciated.Sincerely yoursHassan

needs context

speaker_own

asserts

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2020-10-16 13:50 Edward C. Holmes open

If Lipkin had discovered SARS-CoV-2 he would have patented it!
2020-10-16 13:50 Kristian G. Andersen open

Maybe he did...
2020-10-16 13:51 Edward C. Holmes open

If you're Batman Lipkin is Lex Luthor.....Lex Useless even
2020-10-16 14:40 Edward C. Holmes open

I just got this:
2020-10-16 14:40 Edward C. Holmes

Dear Edwards, It would be appreciated if you would help me with the following questions on viral evolution. I want to work on predicting the next viral crisis, but I don't have a clear picture of my idea on this. Here is the idea: One of the main steps in zoonotic transfer is the ability of an animal virus to enter human respiratory cells. So wecan list all surface proteins of human epithelial cells (in the respiratory tract) and then using molecular docking wepredict (viral) complementary proteins. Viruses with these proteins can potentially enter human cells. By translatingthese proteins into nucleotides, we have a list of potentially dangerous viruses; some of them are not yet evolved. Using modeling we can estimate the required time for evolving these viruses from currently available viruses and finally figure out how far we are from the next viral crisis.1. Is this proposal meaningful scientifically?2. Is it already done?3. Any suggestion and comment on this is appreciated.Sincerely yoursHassan
2020-10-16 14:40 Edward C. Holmes open

I have a few for 3. :man-facepalming:
2020-10-16 14:43 Kristian G. Andersen open

I think this bit "I don't have a clear picture of my idea on this" in particular rings true.
2020-10-16 14:44 Andrew Rambaut open

Pass it on to Lipkin, Edwards
2020-10-16 14:45 Kristian G. Andersen open

#mean

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