Private channel session 373
4 messages over 40m, 2020-09-12 – 2020-09-12.
A “conversation” here is an activity session — a run of messages with under 60 minutes of silence inside it. The channel had no native conversation boundaries.
-
Great job on the OpEd Eddie - the brilliance shines thru even with a heavy-handed editor.
-
I'm a little more optimistic that immunity, natural or vaccine, will impact the spread of SARS-CoV-2. As Kristian knows [please keep this to the channel] we've found a fairly high level of serorxty to several SARS-CoV-2 proteins,N, S, RDB in Sierra Leonean samples going back several years. Some of the samples neutralize SARS-CoV-2pseudovirus. Probably a related betacoronavirus, but not a known seasonal CoV [HKU-1 or OC43]. May help explain (and I can't really fathom a lot of other explanations) why SARS-CoV-2 has not exploded in most of Africa. We're trying to get a dataset to post ASAP on Virological.
-
Unrelated - I'm looking for a good current Nidovirus tree. Fig 7 here seems good but I'm the *last* to judge a tree:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211748/ Other trees I've seen have artiviruses closer to toroviruses,but I think that's not correct. I've been looking at some of the spikes of non-CoV Nidoviruses - many have furin sites -some have YUGE mucin-like domains. S2s are more flu-like (one long helix/leash) than the CoV S2s.
-
I'm hopeful vaccines will be able to get us to where we need to be immunity wise, just not so sure about natural immunity and how long-lasting it is - but even if it isn't, there's still no doubt that it's already helping to drive down cases in at-risk areas. Let's see what happens in NYC this late fall / winter... Looking forward to seeing those cross-reaction results - very interesting!