Chat message

Slack / Private Message Drop, p.110 [SLACK_000324] · slack_pm:msg:01121

Date: 2020-07-27 15:03
Type: chat message · slack
recipient: Kristian G. Andersen, Edward C. Holmes, Andrew Rambaut
speaker: Robert F. Garry

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Yeah - that's a good idea - you could get down to the best set of candidates with 10-20 person trials in a few months. Same with the monoclonals, though showing protection in animals before the in-ppl screening would be good.

In context

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2020-07-27 14:46 Kristian G. Andersen open

"This virus doesn't lurk unobserved" - as is, definitely true - but I _do_ wonder if a pre-furin site virus could. But Iagree with you - I'm not sure such an analysis makes sense given our limited sampling. Assuming SARS2 came outof Yunnan diversity (which seems likely), it would be cool to go do some in-depth sampling from there. And yes, maybe we'll get the big reveal on Twitter :wink:
2020-07-27 14:48 Andrew Rambaut open

But if the acquisition of the furin site is the point at which it becomes epidemic then once again we are back to the common ancestor of the current diversity being in late 2019. We don't have any other nodes to date.
2020-07-27 14:50 Kristian G. Andersen open

.... ehm, yes. That is, of course, true... Unless it's been in a freezer since that outbreak in the Mojiang mine...:parrot:
2020-07-27 14:55 Kristian G. Andersen open

And @Robert Garry - I have come around on challenge testing... What I really want to see is early challenge trials invery small (~10-20) groups of people to establish efficacy. If it doesn't work in those, no need to move forward... I'm SUPER uncomfortable with 30,000 people now getting the Moderna vaccine - can you imagine how detrimental thisis going to be for (COVID and otherwise) vaccine research if this vaccine actually isn't safe? Or may even lead toADE?Let's hope it works...
2020-07-27 15:03 Robert F. Garry

Yeah - that's a good idea - you could get down to the best set of candidates with 10-20 person trials in a few months. Same with the monoclonals, though showing protection in animals before the in-ppl screening would be good.
2020-07-27 15:09 Kristian G. Andersen open

Yup.
2020-07-27 15:09 Kristian G. Andersen open

Okay, so back to topic - Eddie and I just received this from Jon. This is serious !channel, so we need to consider this carefully. [shared file(s): Screen Shot 2020-07-27 at 3.08.41 PM.png]
2020-07-27 15:10 Robert F. Garry open

Moderna trial started today in Louisiana BTW
2020-07-27 15:13 Kristian G. Andersen open

Who the hell could this person be? Obviously the person gets some of the details (and intentions) wrong, but everything is otherwise pretty much correct - that is so extremely deep knowledge about how this played out.

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