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Slack / Private Message Drop, p.94 [SLACK_000308] · slack_pm:msg:00956

Date: 2020-07-04 09:31
Type: chat message · slack
recipient: Kristian G. Andersen, Robert F. Garry, Edward C. Holmes
speaker: Andrew Rambaut

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There are lots of confounding things going on here - the later weeks have lots more Gs (although there are some persistent D lineages) but there was a switch to hospital based testing and a lot of hospital workers were sequenced- tending to be younger.

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2020-07-04 09:12 Kristian G. Andersen open

@Andrew Rambaut, great analysis in the COG report: https://www.cogconsortium.uk/wp-content/uploads/2020/07/2 5th-June-2020-Report-COVID-19-Genomics-UK-COG-UK-Consortium.pdf Question about this part: "As reported in a preliminary analysis of D614G (See COG-UK report #6), a significant association was observed between the age of patients and the probability of the virus carrying D614G, with decreasing odds of carrying the G variant as age increases. However, the basis for this association remains unclear and may also result from sampling bias." Are you guys able to isolate the effect of time here? There has been a general trend towards more recent infections being (heavily) biased towards younger people and since Doug is younger than Dougless I'd kinda expect this tohappen.
2020-07-04 09:31 Andrew Rambaut

There are lots of confounding things going on here - the later weeks have lots more Gs (although there are some persistent D lineages) but there was a switch to hospital based testing and a lot of hospital workers were sequenced- tending to be younger.
2020-07-04 09:33 Kristian G. Andersen open

Yeah, that's what I thought - likely explains the shift towards younger people in G. (hence the need to try and control for that confounder, but likely not really possible).

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