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Slack / Private Message Drop, p.86 [SLACK_000300] · slack_pm:msg:00878

Page text: p.86 · original PDF

Date: 2020-06-18 18:39
Type: chat message · slack
recipient: Kristian G. Andersen, Robert F. Garry, Andrew Rambaut
speaker: Edward C. Holmes

Recipients on this medium are inferred from channel membership, not per-message addressing.

Tommy's paper very clearly stated the provenance. Can't speak for the others.

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2020-06-18 18:26 Kristian G. Andersen open

Here's the manuscript from her - please keep confidential. I haven't read it yet. [shared file(s): Matters Arising ChanZhan 2020.pdf]
2020-06-18 18:28 Kristian G. Andersen open

I think the main problem here is not really how that pangolin sequence ended up having that RBD, but rather whether there's anything sketchy here from a scientific standpoint. These studies are presented each as independent evidence of the pangolin virus RBD, but if all those papers are relying on a third data set - and don't actually have _any_ data from this very critical CoV RBD, then that's an issue.
2020-06-18 18:30 Kristian G. Andersen open

I don't really see how this changes anything from the evolutionary perspective - because seeing it even once is very strong evidence. But there's no denying that if these studies have to be modified (or possibly even retracted), then that is going to send a nuke into the whole evolution conversation - whether justified or not.
2020-06-18 18:36 Edward C. Holmes open

Can we do a quick Zoom now.
2020-06-18 18:39 Edward C. Holmes

Tommy's paper very clearly stated the provenance. Can't speak for the others.
2020-06-18 18:40 Kristian G. Andersen open

https://us02web.zoom.us/j/9673242666
2020-06-18 19:14 Edward C. Holmes open

Hi Eddie, Although the pangolins used in Liu's study overlap with ous, we did not used Liu's data in this new paper,and assemble four new virus genomes. In addition, we amplied and sequenced (Sanger sequencing) the complete S genes from lung tissues and virus isolate independently, and comfirm the high-throughput sequencing. As showed inFigure S2, the new genomes almost the same as our previous genome and Lam's. Therefore, i am sure that the previous data is correct.I have discussed with Liu several days ago, he also used Sanger sequencing to attain a nearly complete genome, and confirm his high-throughput result. The latest data in this new article will reassure everyone.Sincerely,Yongyi Shen [shared file(s): image.png]
2020-06-18 19:24 Edward C. Holmes open

Just to spice things up, Australia is currently experiencing a state-sponsored cyber-attack that is widely believed tobe from China.
2020-06-18 19:26 Kristian G. Andersen open

.... this won't end well.

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