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Slack / Private Message Drop, p.74 [SLACK_000288] · slack_pm:msg:00747

Date: 2020-06-11 22:48
Type: chat message · slack
recipient: Kristian G. Andersen, Robert F. Garry, Andrew Rambaut
speaker: Edward C. Holmes
Topics: Furin cleavage site and molecular features

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Sorry to keep going, but HKU1 is really interesting in this context: (i) has an furin cleavage site (RRKRR) in the right spot; (ii) causes human and has spread (it turned up in Australia; (iii) betacoronavirus; (iv) closest relative is MHV but that is way distant. Could easily be out a bat or another mammal. No one suggested lab escape when this first appeared. [shared file(s): 1828-04.pdf]

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Statement	Grade	Attribution	Stance
Sorry to keep going, but HKU1 is really interesting in this context: (i) has an furin cleavage site (RRKRR) in the right spot; (ii) causes human and has spread (it turned up in Australia; (iii) betacoronavirus; (iv) closest relative is MHV but that is way distant.	own voice, substantive	speaker_own	asserts

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own voice, substantive

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In context

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2020-06-11 21:26 Kristian G. Andersen open

> would you expect a clinically similar infection in an animal in nature if this had come out of a lab? Don't think one would have an expectation one way or the other - but interesting nonetheless. I find it peculiar that all these pangolins are showing up sick with all sorts of SARS-like CoVs though - I mean, these guys have been traded_forever_ and only now do we realize they have CoVs? Potentially a huge reservoir out there... which is scary.
2020-06-11 21:40 Edward C. Holmes open

Agreed. No one gives a shit and now we are seeing loads of pangolins with frothy lungs. You couldn't make this up.
2020-06-11 21:47 Edward C. Holmes open

Notable that HKU1 does have a furin cleavage site but NL63 doesn't. To me, this trait moves around so much in nature that we can't really say anything: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1866027/
2020-06-11 21:49 Edward C. Holmes open

And they weren't able to culture HKU1.
2020-06-11 22:48 Edward C. Holmes

Sorry to keep going, but HKU1 is really interesting in this context: (i) has an furin cleavage site (RRKRR) in the right spot; (ii) causes human and has spread (it turned up in Australia; (iii) betacoronavirus; (iv) closest relative is MHV but that is way distant. Could easily be out a bat or another mammal. No one suggested lab escape when this first appeared. [shared file(s): 1828-04.pdf]
2020-06-11 23:41 Andrew Rambaut open

This is interesting (can't find original research) https://www.fli.de/en/press/press-releases/press-singleview/novel-coronavirus-sars-cov-2-fruit-bats-and-ferrets-aresusceptible-pigs-and-chickens-are-not/Shows infection in Rousettus fruit bats (i.e., where HKU9 was found).

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