A single line often inverts meaning once you see what it
answers, so neighbouring messages are always shown.
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My take is that furin cleavage sites are *everywhere* in natural viruses e.g. MERS. I'm revising a paper on avianavulaviruses and they have one. To me, there is a strong natural prior.
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Yes - I have been aware of the Follis paper all along - I was _not_ aware that their insertion was exactly where it is inSARS2
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Also, the Zhou et al. paper never call it a furin cleavage site insertion and I think the alignment in that paper is the optimal one. If so, it is not a simple 'shift' but rather a complex set of indel events.
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Here's the paper from Baric - not the insertion, but showing that cleavage broadens host range (https://pubmed.ncbi.nlm.nih.gov/31801868/) - which is what furin does. This is also not a new paper - I have been aware of this all along as well, so not a smoking gun, but there are several concerns here related to tissue culture
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2020-06-11 15:21
Kristian G. Andersen
I don't think the Zhou et al. paper shows that this is multiple indels - to me it just looks like a region not aligning very well?
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Let me spend some time on a table with things that bothers me - because there are several.
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That would be useful. Thanks.
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Yeah, let me get it all down - including the silly stuff :wink:
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Make sure there is a column in your table that can be used for 'possible natural explanation'. For example, I don't see why adaptation in animals/culture would then produce a virus that would need not to adapt in humans themselves.