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Slack / Private Message Drop, p.55 [SLACK_000269] · slack_pm:msg:00554

Page text: p.55 · original PDF

Date: 2020-06-05 12:23
Type: chat message · slack
recipient: Kristian G. Andersen, Edward C. Holmes, Andrew Rambaut
speaker: Robert F. Garry

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<file:///Users/robertgarry/Downloads/elife-58603-v1%20(1).pdf>

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2020-06-05 11:42 Kristian G. Andersen open

Different virus, but this new RTT plot for Ebola is super interesting. @Andrew Rambaut have you been looking into this? Different reservoir host? [shared file(s): root-to-tip-with-labels.jpg]
2020-06-05 11:44 Andrew Rambaut open

@Kristian Andersen Fits perfectly with the idea of two episodes of latency: https://beast.community/ebov_local_clocks.html
2020-06-05 11:45 Andrew Rambaut open

@Kristian Andersen We have a paper in prep. Will need to add this new one in.
2020-06-05 11:50 Kristian G. Andersen open

@Kristian Andersen Yup. Super interesting - I had never really thought of this as a lineage thing, more as independent events. Strongly suggesting there might be different strains of Ebola virus living in different reservoirs -either due to geographical differences, or differences in the virus host range. This screams for a formal analysis :wink:
2020-06-05 12:23 Robert F. Garry

<file:///Users/robertgarry/Downloads/elife-58603-v1%20(1).pdf>
2020-06-05 12:25 Robert F. Garry open

This is kinda interesting as well.
2020-06-05 12:35 Robert F. Garry open

```1 megnkleeqd ssppqstpgl mkgnkreeqg lgpepaapqq ptaeeealie fhrsyrelfe 61 ffcnnttihg airlvcsqhn rmktafwavl wlctfgmmyw qfgllfgeyf sypvslninl 121 nsdklvfpav tictlnpyry peikeeleel driteqtlfd lykyssfttl vagsrSrrdl 181 rgTlphplqr lrvpppphga rrarSvasSl rdnnpqvdwk dwkigfqlcn qnksdcfyqt 241 yssgvdavre wyrfhyinil srlpetlpsl eedtlgnfif acrfnqvscn qanyshfhhp 301 mygncytfnd knnsnlwmss mpginnglsl mlraeqndfi pllstvtgar vmvhgqdepa 361 fmddggfnlr pgvetsismr ketldrlggd ygdctkngsd vpvenlypsk ytqqvcihsc 421 fqesmikecg cayifyprpq nveycdyrkh sswgycyykl qvdfssdhlg cftkcrkpcs 481 vtsyqlsagy srwpsvtsqe wvfqmlsrqn nytvnnkrng vakvniffke lnyktnsesp 541 svtmvtllsn lgsqwslwfg ssvlsvvema elvfdllvim flmllrrfrS rywSpgrggr 601 gaqevaSTla SSppShfcph pmSlSlSqpg papSpalTap ppayaTlgpr pSpggSagaS 661 sstcplggp``` So, mo fun with BLAST which should raise an eyebrow BUT - Also PREDICTED *O-glycans* (I CAPPED them) *around the furin site* RRARSVAS (yes it's identical to SARS-CoV-2) - *hmmm* and a big predicted mucin-like domain at the C -terminus. Just a reminder that HKU1 and OC43 spikes also have big predicted mucin-like domains in "place" of the ACE-2 RBD.
2020-06-05 12:42 Kristian G. Andersen open

Bob - PDF is in your personal drive :wink:
2020-06-05 12:48 Robert F. Garry open

https://elifesciences.org/articles/58603

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