Chat message

Slack / Private Message Drop, p.54 [SLACK_000268] · slack_pm:msg:00539

Date: 2020-06-04 17:21
Type: chat message · slack
recipient: Kristian G. Andersen, Robert F. Garry, Edward C. Holmes
speaker: Andrew Rambaut

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It is really annoying - those BC sequences that sit between WA1 and WA2 cluster are almost certainly artefacts (the second defining mutation is in a primer site and they are calling it for the primer). Happens with some of the other BCones in the WA2 cluster too.

In context

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2020-06-04 17:18 Andrew Rambaut open

Go full Trevor?
2020-06-04 17:18 Kristian G. Andersen open

Indeed (actually, he's chatting me right now about that new 'paper')
2020-06-04 17:19 Andrew Rambaut open

It is my retirement project - become a creationist.
2020-06-04 17:20 Kristian G. Andersen open

Get the Templeton Prize > that's your ticket
2020-06-04 17:21 Andrew Rambaut

It is really annoying - those BC sequences that sit between WA1 and WA2 cluster are almost certainly artefacts (the second defining mutation is in a primer site and they are calling it for the primer). Happens with some of the other BCones in the WA2 cluster too.
2020-06-04 17:21 Andrew Rambaut open

But the folk in the BCCDC won't do anything about it until they have checked it with sanger sequencing
2020-06-04 17:21 Kristian G. Andersen open

Eh? Don't they trim primers? iVar does that...
2020-06-04 17:23 Andrew Rambaut open

I don't know the details. It was Nick that was discussing it with them.
2020-06-04 17:23 Kristian G. Andersen open

Hmmm. They certainly should. Does this affect the conclusions from your recent preprint?

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