A single line often inverts meaning once you see what it
answers, so neighbouring messages are always shown.
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I hope those fuckers slip in the shower.
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Just got sent this as well.
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https://www.youtube.com/watch?v=eD3ztjqYGbg
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Yeah, I think that's the one I shared too? The amount of stupidity makes my head hurt.
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2020-05-12 21:12
Edward C. Holmes
There's so many I've lost track!
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Bob/Kristian - can you give me your latest thinking about whether any lab manipulation would involve cell culture orlive animal passage? Can we exclude the former?
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Yeah, either cell culture or animal passage. I find animal passage to be unlikely, since those are complicated experiments. I'm starting to worry about cell culture again because of some of the things we're noticing in the cell culture sequencing experiments (plus all their historical work of exactly that type of work - but we have already discussed that).
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What do we now think about the o-linked glycans and the low dn/ds values? Can they be used to rule anything in/out?
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Initially we thought the O-linked glycans could somewhat rule out lab culture (or wouldn't be consistent with), but I'm much less sure now - I'm not convinced they actually form a glycan shield and instead may help regulate the site itself. The low dN/dS value - primarily in the spike - has always been peculiar to me and a tiny bit suggestive ofculturing.