Transcript segment
Baric Transcribed Interview (Redacted), pp.24-25 · baric_ti:utt:00137
Page text: p.24, p.25 · original PDF
- Date
- 2026-04-10 09:00 (day precision)
- Type
- transcript segment · interview
- recipient
- Christina Salazar, Harry Kazenoff, David T. Lambeth III, William Henderson, Clark Ervin, Jake Greenberg
- speaker
- Ralph S. Baric
Okay. Around 2013 or 2014, Zhengli Shi
identified two new sarbecoviruses called SHC014 and WIV1.
She was able to culture WIV1 in cell culture, and they
published a paper in Nature on that. And we met at a
meeting and we had some discussions. Ultimately, she
provided me with the sequences, and we used that, of the
spike, going at the spike like a protein. And so we build
chimeric viruses.
DC.Scheduling@LexitasLegal.com
They also, when the paper was finally being written,
they had developed what are called pseudotype viruses.
These are, in essence, single-hit replicon viruses that are
pseudotyped with the spike like a protein, of different
coronaviruses. And they showed that WIV1 could infect and
use human H2 receptors. But they also showed that SHC014
could not. So when she provided us with those reagents and
we recovered viruses, we showed that SHC014, in fact, could
use that human receptors for entry. And because they also
provided their SHC014 pseudotype data in the paper and
provided the virus sequences for this, they were included
on the manuscript, and I think their grant was cited. So
that's how that worked.