Private channel session 862

17 messages over 2h 8m, 2021-01-23 – 2021-01-23.

A “conversation” here is an activity session — a run of messages with under 60 minutes of silence inside it. The channel had no native conversation boundaries.

1. 2021-01-23 13:20 Edward C. Holmes open PDF p.441
   @Robert Garry The sequence of the Cambodian bat virus is now on GISAID. Not sure if you have it. Also, do you/we plan to write-up these Virological posts into a paper? Things are moving quickly though.
2. 2021-01-23 13:39 Andrew Rambaut open PDF p.441
   More seriously - what would be the optimal FCS?
3. 2021-01-23 13:41 Andrew Rambaut open PDF p.441
   And of course optimal cleavage may not have peak fitness benefit to the virus - you can presumably cleave too well and alter some other trade off in the dynamics.
4. 2021-01-23 14:28 Andrew Rambaut open PDF p.441
   Genomes - England per day. Red = B.1.1.7, Blue = B.1.177, Grey = the rest [shared file(s): image.png]
5. 2021-01-23 14:36 Edward C. Holmes open PDF p.441
   Just going through my emails for the GIPA crap. Some are poignant. [shared file(s): Screen Shot 2021-01-24 at 9.27.27 am.png]
6. 2021-01-23 14:37 Edward C. Holmes open PDF p.441
   Note the date
7. 2021-01-23 14:40 Andrew Rambaut open PDF p.441
   Will these be made public?
8. 2021-01-23 14:46 Edward C. Holmes open PDF p.441
   No plans to. They don't directly relate to the paper.
9. 2021-01-23 14:51 Robert F. Garry open PDF p.441
   @Andrew Rambaut Agree with this - optimal cleavage might vary depending on multiple factors - cleave in the wrong tissue or wrong time not good. - An optimal cleavage site is RRXRR. Not all X's equal so RRRRR among the best.
10. 2021-01-23 14:52 Edward C. Holmes open PDF p.442
    But I can of course use them if necessary.
11. 2021-01-23 14:53 Andrew Rambaut open PDF p.442
    True - would be interesting if some of that got out (doesn't look good for CCDC)
12. 2021-01-23 14:54 Edward C. Holmes open PDF p.442
    Oh no.
13. 2021-01-23 14:57 Robert F. Garry open PDF p.442
    Wow.
14. 2021-01-23 14:58 Robert F. Garry open PDF p.442
    "Also, do you/we plan to write-up these Virological posts into a paper?" yes - needed! on it.
15. 2021-01-23 15:05 Kristian G. Andersen open PDF p.442
    Whoa Eddie - that's pretty scary language in that email.
16. 2021-01-23 15:28 Edward C. Holmes open PDF p.442
    Yes, very bad. You know, all the bad stuff that came out of this, all the attacks that are ongoing, are due to George Gao. No doubt.
17. 2021-01-23 15:28 Edward C. Holmes open PDF p.442
    Thanks for working on the paper Bob!