Slack / Private Message Drop — page 817

[2021-05-15 17:29:04] [Eddie Holmes] CoV-HKU1 was first described in Shenzhen. [2021-05-15 17:29:22] [Kristian Andersen] So we really need to answer the question - how unusual is Wuhan for something like this to happen? I don't think very unusual - animal markets, top-10 largest city, largest city in central China, etc. [2021-05-15 17:29:59] [Kristian Andersen] Really? [2021-05-15 17:32:51] [Eddie Holmes] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC538593/ [2021-05-15 17:33:29] [Kristian Andersen] ... and SARS-CoV-1 in Foshan. I mean, these are big places - like Wuhan. [2021-05-15 17:34:02] [Eddie Holmes] HKU-1. 1. Emerged in massive Asian city; 2. Unknown animal origin; 3. Furin cleavage site; 4. Initially associated with pneumonia. Sound familiar? [2021-05-15 17:35:01] [Kristian Andersen] FUCK EDDIE - THAT CAME FROM THE LAB TOO??!!!!!!!! [2021-05-15 17:35:26] [Kristian Andersen] It's the same thing all over again. [2021-05-15 17:36:51] [Eddie Holmes] It is! I've mentioned HKU1 in virtually every talk I've given over the last 14 months. Just look at that JVI paper. You could just transpose SARS-CoV-2 for CoV-HKU1. [2021-05-15 17:37:26] [Kristian Andersen] Yeah, reading it now - it really is exactly the same story all over again. Except, more benign virus. [2021-05-15 17:38:38] [Kristian Andersen] This is good - because if we can kill the "Wuhan isn't so special", it'll help turn over a lot of people. Would also help if we had a good sense of where major labs are. [2021-05-15 17:38:39] [Eddie Holmes] Initially a pneumonia patient. [2021-05-15 17:40:11] [Eddie Holmes] As there was no major outbreak of pneumonia people lost interest, but it's all there.