Slack / Private Message Drop — page 587

All taken from comments of !channel [2021-03-11 11:09:23] [Robert Garry] Origins and evolution of SARS-CoV-2? Could include some things about pathways to the variants as well I think. It all relates - SC2 more pantropic than human adapted, but its getting better at infecting us. [2021-03-11 11:14:33] [Robert Garry] Also working on an update to Holmes2021 virological post - including the new Weifeng viruses from the garden. [shared file(s): image.png] [2021-03-11 11:19:25] [Robert Garry] O-glycans included here in the N terminus, but also some "new" ones near the S1/S2 junction. Hard to think that this is all just coincidence. [2021-03-11 11:20:04] [Robert Garry] Also updating Figure 2, but not quite there yet. [2021-03-11 11:20:32] [Eddie Holmes] Thanks Bob! There's another close bat CoV on GISAID - PrC31 I think. Also from Yunnan. This is from the China CDC. Paper being written up apparently. [2021-03-11 11:22:08] [Robert Garry] Will check it out! [2021-03-11 11:37:37] [Robert Garry] It's VERY close to RpYN06 in spike. [shared file(s): image.png] [2021-03-11 11:45:06] [Robert Garry] Very close [shared file(s): image.png] [2021-03-11 11:46:44] [Kristian Andersen] [thread - ID: 2021-03-11 11:46:44] @Andrew Rambaut - reading the most recent PHE report on VOCs/VOIs (so good!), is it fair to say that non-B.1.1.7 VOCs just aren't that successful in the UK compared to B.1.1.7? Enough data to make that conclusion? Separately, is it fair to say that B.1.1.7 lineages with mutations such as E484K don't appear to be any more successful than 'vanilla' B.1.1.7? [2021-03-11 11:47:19] [Eddie Holmes] Interesting! [2021-03-11 12:52:19] [Kristian Andersen] Hmmm (link not accessible) [shared file(s): Screen Shot 2021-03-11 at 12.51.55.png] [2021-03-11 12:52:22]