Slack / Private Message Drop — page 585

[2021-03-10 14:37:16] [Andrew Rambaut] Was just looking for intermediates of B.1.1.7 - i.e., perhaps involved in the genesis events. Came across a bunch with some of the mutations but not all. The best ones were some that had multiple genomes so were clearly transmitting - but the cool thing is they were sequenced in different labs so no lab funny business. Probably loads more but these are the low hanging fruit (about 5-6 sets) [2021-03-10 14:38:58] [Kristian Andersen] Interesting - not really surprised. So Bette is right? As in, her analyses are right? [2021-03-10 14:42:53] [Andrew Rambaut] Once again Bette got the right answer but is using flawed methods. Her 3-sequence recombination method can't distinguish recombination from convergence. [2021-03-10 14:43:07] [Andrew Rambaut] But recombination is no surprise to any one. [2021-03-10 14:56:51] [Kristian Andersen] That's what I thought - and yeah, recombination is absolutely no surprise to anybody who's been following this virus. I can assure you Bette will make full use of being wrongly right, though.... [2021-03-10 15:04:44] [Kristian Andersen] Eddie - you're killing me... [shared file(s): Screen Shot 2021-03-10 at 14.36.44.png] [2021-03-10 15:09:28] [Robert Garry] I remember a tale of "rightfully" wrong back in the Ebola days https://science.sciencemag.org/content/353/6300/658.1.full https://pubmed.ncbi.nlm.nih.gov/27516593/ Rambaut et al show that the erratum to our report on Ebola virus Makona evolution not only corrected sample dates modified by others in GenBank but also corrected an additional transcriptional error in our original analysis. We agree with their observation that both factors contributed to our revised evolutionary rate estimate but continue to stand by our revised estimate and conclusions. [2021-03-10 15:12:58] [Eddie Holmes] Oh, I remember that one well! [2021-03-10 15:48:02] [Robert Garry] https://onlinelibrary.wiley.com/doi/10.1002/bies.202000325 [2021-03-10 15:50:49] [Robert Garry] taking Segreto and Deigin to task. [2021-03-10 15:55:23] [Eddie Holmes] Thank you Russia! [2021-03-11 04:48:29] [Robert Garry]