Slack / Private Message Drop — page 555

Zambia Zimbabwe``` Notice any commonalities? [2021-02-28 12:52:02] [Andrew Rambaut] [thread - ID: 2021-02-28 12:50:56] Had a long conversation with her explaining why her one example 'recombinant' probably wasn't. [2021-02-28 12:52:35] [Kristian Andersen] [thread - ID: 2021-02-28 12:50:56] @Eddie Holmes Did she listen? She never listens.... [2021-02-28 12:52:35] [Eddie Holmes] Did she believe you? [2021-02-28 12:52:51] [Andrew Rambaut] Of course not. [2021-02-28 12:53:33] [Andrew Rambaut] Her group has some hokey triplet method which is totally useless as you don't have an outgroup [2021-02-28 12:54:15] [Andrew Rambaut] Basically she found a 'californian' virus with 69/70 deletion in it and was claiming it was recombinant with a B.1.1.7. But 69/70 comes up all the time. [2021-02-28 12:54:31] [Andrew Rambaut] I spent way too long on it. [2021-02-28 12:55:25] [Kristian Andersen] Wait, she specifically said 69/70 came from B.1.1.7 and hence it must be a recombinant? That's, well, dumb. Very. [2021-02-28 12:56:04] [Eddie Holmes] What an idiot. I look forward to reviewing that for Cell. [2021-02-28 12:58:23] [Andrew Rambaut] That was the only homoplasy but she had a convincing looking plot of the two 'parents' and the 'recombinant' and it showed a tract in spike that looked like B.1.1.7 compared to the other parent. But it was actually also the same as the reference and the other parent had had some mutations. Just so dumb [2021-02-28 12:59:15] [Andrew Rambaut] The worse thing is we started the meeting with an explanation from Bette about how you detect recombination in viruses.