Slack / Private Message Drop — page 1103

Glad you like it - we went through several versions - ultimately going with a close-up of the Wall of crazy - my original sketch was too much like a Where's Waldo and too much insider stuff (although I liked it). Science would not have liked animals in cages on the cover. [shared file(s): Garry Lab Science Cover_Detail_Concepts v2 (2).pdf] [2022-04-08 07:16:38] [Andrew Rambaut] Anyone for BA.4 and BA.5? Straight out of Gauteng/Botswana. Estimated MRCA Nov 2021 [2022-04-08 07:17:30] [Andrew Rambaut] Has 69/70del (unlike BA.2) and SGTF (and cases) rising in South Africa. Cases in UK, Denmark, Germany - probably elsewhere now [2022-04-08 07:21:36] [Kristian Andersen] :see_no_evil: :hear_no_evil: [2022-04-08 07:22:23] [Kristian Andersen] MRCA with BA.1/2? [2022-04-08 07:22:25] [Andrew Rambaut] Tulio is cooking these up in his GOF lab [2022-04-08 07:22:39] [Andrew Rambaut] No - MRCA within BA.4 [2022-04-08 07:22:45] [Andrew Rambaut] It is weird [2022-04-08 07:22:57] [Andrew Rambaut] Doesn't look like a new selective sweep. [2022-04-08 07:23:41] [Andrew Rambaut] Perhaps it was circulating all the time but is now in a slight advantage due to the unusual immune landscape in RSA. Or.... [2022-04-08 07:23:49] [Andrew Rambaut] perhaps we are all fucked again [2022-04-08 07:24:05] [Andrew Rambaut] There are details in the UKHSA tech briefing today [2022-04-08 07:24:46] [Kristian Andersen] I'm pretty darn convinced BA.1 infection leads to pretty crappy immunity so a slight advantage in evasion while maintaining R0, well... [2022-04-08 07:25:36]