Slack / Private Message Drop — page 1001

[2021-09-21 08:49:44] [Kristian Andersen] Culture is very challenging so I don't think that approach makes sense. [2021-09-21 09:00:15] [Kristian Andersen] Here's what I suggest we do: • Make (spike) alignments with SC1, SARSr-CoVs, RaTG13(+close friends), Pangos, BANAL, SHC014, rs4237, SC2 • Mark 'key' sites based on what's in the grant - @Robert Garry, can you please help highlight the N-linked glycans based on Wuhan Hu-1 coordinates • Check to see if there's anything odd between SC2, basal viruses, and SC1 • Look at e.g., codon usage at those sites if anything stands out • Cross-check with how those sites have evolved during the pandemic [2021-09-21 09:01:22] [Andrew Rambaut] And stay off email [2021-09-21 09:02:00] [Andrew Rambaut] Or carefully curate some emails for the FOI records [2021-09-21 09:07:39] [Robert Garry] OK I'm on my bit... [2021-09-21 09:07:43] [Kristian Andersen] Exactly - let's dig around a little and then start an email chain. I'm in Zoom calls most of the day, but I'll dive in in the afternoon. [2021-09-21 09:09:52] [Kristian Andersen] Actually, let me get started - I just cleared my calendar for the next hour. [2021-09-21 09:34:20] [Robert Garry] Is this a good set for the SC1 related viruses - or others (some more civet ones)? [shared file(s): image.png] [2021-09-21 09:35:11] [Kristian Andersen] I'm getting (and annotating) the genomes now [2021-09-21 09:37:43] [Andrew Rambaut] Ooh.. Can't wait. [2021-09-21 09:39:31] [Andrew Rambaut] Probably worth having the full genomes aligned even if we only focus on the close relatives in the spike [2021-09-21 09:41:18] [Kristian Andersen]