Gates Package — page 1357
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©
ENGINEER B CELLS
Can we use stem cell engineering and
differentiation technologies to produce
Hematopoietic
B-cell
Long-Lived I
Universally
lono-li
ong-lived B-cells?
stem Gell
Stem Cell
B-cell ve
applied
a
Genetically
oe
it
iI
it
FUTL
TATE
introdu
cA
'SOY
Designer B cells producing antibody /
Add
|Delete
therapeutic protein delivered by
gene I gene
I
injection
Universal cells that
Antibody
Low dose of
evade immunity
production
B-cells
for decades
to achieve
protection
Infectious disease and other applications
that require long-term, stable antibody
production
PARTNERS:
tappy
ow
INCENTIVES: Regulatory guidance/clarity for approval processes on
ns
severe disease endpoints, costing infrastructures (to be developed)
©.) Scripps Research
"
EMORY
Hosphtal
UNIVERSITY
G if
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Records on this page
| Record | Date | Type | Pages |
|---|---|---|---|
| gates:exh:00636 | — | attachment | 1357 |