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© ENGINEER B CELLS Can we use stem cell engineering and differentiation technologies to produce Hematopoietic B-cell Long-Lived I Universally lono-li ong-lived B-cells? stem Gell Stem Cell B-cell ve applied a Genetically oe it iI it FUTL TATE introdu cA 'SOY Designer B cells producing antibody / Add |Delete therapeutic protein delivered by gene I gene I injection Universal cells that Antibody Low dose of evade immunity production B-cells for decades to achieve protection Infectious disease and other applications that require long-term, stable antibody production PARTNERS: tappy ow INCENTIVES: Regulatory guidance/clarity for approval processes on ns severe disease endpoints, costing infrastructures (to be developed) ©.) Scripps Research " EMORY Hosphtal UNIVERSITY G if Not for distribution