Gates Package — page 1330

® Preliminary MANIPULATE CELL STATE AND FATE CAN WE APPLY RATIONAL CONTROLS TO IMMUNE AND STEM CELLS? Rational controls in biol ie LNP ----~», Hematopoietic @ & stem cell input Cell state Differentiated cell outputs outputs @ =@ antigen can be used to define these Music analogy Antigen input What controls varied outputs? Identify models and frameworks to define biological controls of immunity and stem cell differentiation What non-genetic perturbations influence cell state and fate? WHAT POTENTIAL RELATIONSHIPS COULD ACCELERATE THIS WORK? The Alan Turing Institute And more, +) including new companies a POSSIBLE APPLICATION(S) Programmable design of nextgeneration vaccines and therapeutics to control specific immune responses Not for distribution} 2