Gates Package — page 1331

® Preliminary PROGRAM IMMUNITY WHAT IS PROGRAMMING IMMUNITY? Antigen Input Immune processing Cell activation Immune outcome RNA stem Toop \ ie Rie + Increase anti-CD118 oteni {oy Dendritic Potency cell (DC) . Improve tNP : durability * Mucosal Q Protection Antigen * Dose Reduction anti-MHC II KEY QUESTION(S) Know and control the location, duration, and specific immune responses How and where are immune signals transduced & processed? WHAT POTENTIAL RELATIONSHIPS COULD ACCELERATE THIS WORK? UNIVERSITY SCHOOL OF MEDICINE ~ And more, +) including new : companies POSSIBLE APPLICATION(S) Fit for purpose, directed vaccines that lead to durable protection from severe disease Not for distribution} 3