Attachment
Gates Package, p.1330 · gates:exh:00617
Page text: p.1330 · original PDF
- Date
- — (unknown precision)
- Type
- attachment · document
- Topics
- Vaccines
® Preliminary
MANIPULATE CELL STATE AND FATE
CAN WE APPLY RATIONAL CONTROLS TO IMMUNE AND STEM CELLS?
Rational controls in biol
ie
LNP ----~»,
Hematopoietic
@
&
stem cell input
Cell state
Differentiated cell
outputs
outputs
@ =@
antigen
can be used to define these
Music analogy
Antigen
input
What controls
varied outputs?
Identify models and frameworks to define
biological controls of immunity and stem cell
differentiation
What non-genetic perturbations influence cell
state and fate?
WHAT POTENTIAL RELATIONSHIPS
COULD ACCELERATE THIS WORK?
The
Alan Turing
Institute
And more,
+) including new
companies
a
POSSIBLE APPLICATION(S)
Programmable design of nextgeneration vaccines and therapeutics
to control specific immune responses
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