Scientists believed Covid leaked from Wuhan lab - but feared debate could hurt 'international harmony' Emails to Dr Anthony Fauci show 'likely' explanation identified at start of coronavirus pandemic, but there were worries about saying so_By_Sarah Knapton, SCIENCE EDITOR11 January 2022 • 9:31pmEmails show scientists seriously discussed the laboratory leak theory, but that they feared the debate could damage science in China CREDIT: Hector Retamal/AFP via Getty ImagesLeading British and US scientists thought it was likely that Covid accidentally leaked from a laboratory but were concerned that further debate would harm science in China, emails show.An email from Sir Jeremy Farrar, director of the Wellcome Trust, on February 2 2020 said that "a likely explanation" was that Covid had rapidly evolved from a Sars-like virus inside human tissue in a low-security lab. The email, to Dr Anthony Fauci and Dr Francis Collins of the US National Institutes of Health, went on to say that such evolution may have "accidentally created a virus primed for rapid transmission between humans". But a leading scientist told Sir Jeremy that "further debate would do unnecessary harm to science in general and science in China in particular". Dr Collins, the former director of the US National Institutes of Health, warned it could damage "international harmony".Viscount Ridley, co-author of Viral: the search for the origin of Covid, said: "These emails show a lamentable lack ofopenness and transparency among Western scientists who appear to have been more interested in shutting down ahypothesis they thought was very plausible, for political reasons."ADVERTISINGIn the emails, Sir Jeremy said that other scientists also believed the virus could not have evolved naturally. One such scientist was Professor Mike Farzan, of Scripps Research, the expert who discovered how the original Sars virus binds to human cells. Scientists were particularly concerned by a part of Covid-19 called the furin cleavage site, a section of the spike protein which helps it enter cells and makes it so infectious to humans.Summarising Professor Farzan's concerns in an email, Sir Jeremy said: "He is bothered by the furin site and has ahard time (to) explain that as an event outside the lab, though there are possible ways in nature but highly unlikely."I think this becomes a question of how do you put all this together, whether you believe in this series ofcoincidences, what you know of the lab in Wuhan, how much could be in nature - accidental release or natural event? I am 70:30 or 60:40."Later emails showed that by February 4, Sir Jeremy had revised his estimate of a laboratory leak to 50:50, while Professor Eddie Holmes, of the University of Sydney, gave a 60:40 estimate in favour of an accidental release. The emails also show that Bob Garry, of the University of Texas, was unconvinced that Covid-19 emerged naturally."I just can't figure out how this gets accomplished in nature," he said. Professor Andrew Rambaut, from the University of Edinburgh, also said that furin cleavage site "strikes me asunusual".He added: "I think the only people with sufficient information or access to samples to address it would be the teams working in Wuhan." The new details came to light after members of the US Republican House Oversight Committee were grantedaccess to the documents, after complaining that their content had been heavily redacted when released under Freedom of Information requests. The emails were sent in response to a teleconference between 12 scientists including Sir Patrick Vallance, theGovernment's chief scientific adviser, on February 1.The emails show that by February 2 2020, scientists were already trying to shut down the debate into the laboratory leak theory.An email from Dr Ron Fouchier to Sir Jeremy said: "Further debate about such accusations would unnecessarilydistract top researchers from their active duties and do unnecessary harm to science in general and science inChina in particular."Dr Collins, former director of the NIH, replied to Sir Jeremy stating: "I share your view that a swift convening ofexperts in a confidence-inspiring framework is needed or the voices of conspiracy will quickly dominate, doing great potential harm to science and international harmony."Institutions which held the emails have repeatedly resisted efforts to publish their content. The University of Edinburgh recently turned down an Freedom of Information request from The Telegraph asking tosee Prof Rambaut's replies, claiming "disclosure would be likely to endanger the physical or mental health and safety of individuals". James Comer, the Republican congressman who secured the unredacted emails, said it showed that experts like DrFauci had taken the Wuhan lab leak theory "much more seriously" than they had let on.Sir Jeremy has been approached for comment but had not replied at the time of publication.