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Slack / Private Message Drop, p.946 [SLACK_001160] · slack_pm:msg:09847

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*Yes from your earlier post (Numbering off by 1) Andrew Rambaut* [12:11 PM] Wuhan-Hu-1: T:8781:C|T:18059:C|C:28143:T WH04: T:18059:C WA1: 0:

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2021-06-19 10:39 Robert F. Garry open

WA1 is lineage A and has bat-like T8782 and C28144 plus another bat-like snp - what mutation is this?
2021-06-19 10:41 Robert F. Garry open

More top secret stuff - Tony and Francis have arranged a call with Jesse tomorrow - need to sort this out...
2021-06-19 10:42 Robert F. Garry open

C18060T?
2021-06-19 11:33 Andrew Rambaut open

```But the earliest known SARS-CoV-2 sequences, whichare mostly derived from the Huanan Seafood Market, are no-tably more different from these bat coronaviruses than othersequences collected at later dates outside Wuhan.``` This is incorrect - WA1 is from Wuhan
2021-06-19 11:34 Robert F. Garry

*Yes from your earlier post (Numbering off by 1) Andrew Rambaut* [12:11 PM] Wuhan-Hu-1: T:8781:C|T:18059:C|C:28143:T WH04: T:18059:C WA1: 0:
2021-06-19 11:34 Andrew Rambaut open

So it is they are notably (2 or 3 mutations) more distant from RATG13 than other viruses in Wuhan at the same time
2021-06-19 11:56 Robert F. Garry open

Yes - he's got WA1 in the mix, but yes definitely WA1 early Wuhan for sure. I'm thinking Jesse making much ado about nothing - it's lineage A going to lineage B with WA1 from Wuhan ancestral.
2021-06-19 12:03 Robert F. Garry open

"Rambaut _et al._ (2020) suggest that viruses from the clade labeled "B" in Figure 4 may just "happen" to have been sequenced first, but that other SARS-CoV-2 sequences are really more ancestral as implied by phylogenetic rooting." Uhhh Rambaut is right about this...