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Slack / Private Message Drop, p.882 [SLACK_001096] · slack_pm:msg:09138

Page text: p.882 · original PDF

Date
2021-05-27 11:15
Type
chat message · slack
recipient
Robert F. Garry, Edward C. Holmes, Andrew Rambaut
speaker
Kristian G. Andersen

Recipients on this medium are inferred from channel membership, not per-message addressing.

Interesting - a couple of B.1.429s with Karen in them too. I thought maybe L452R would be non-conducive to Karen.... https://outbreak.info/compare-lineages?gene=S&threshold=75

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  1. 2021-05-27 10:14 Kristian G. Andersen open
    First quote: "ALINA CHAN We are in this pandemic that's been ongoing for about one and a half years now, there has been no actual investigation of how it began". Unbelievable.
  2. 2021-05-27 10:30 Robert F. Garry open
    And the so-called reporter - not a peep to question that.
  3. 2021-05-27 10:56 Kristian G. Andersen open
    Brooke Gladstone - of all people. Disappointing.
  4. 2021-05-27 11:11 Andrew Rambaut open
    In other news we are tracking a B.1.617.2 variant variant with K417N (Karen) - probably at quite high prevalence inNepal with lots of travel exports. Looks nasty.
  5. 2021-05-27 11:15 Kristian G. Andersen
    Interesting - a couple of B.1.429s with Karen in them too. I thought maybe L452R would be non-conducive to Karen.... https://outbreak.info/compare-lineages?gene=S&threshold=75
  6. 2021-05-27 11:52 Andrew Rambaut open
    But add 'more transmissible than B.1.17' and it could be a problem
  7. 2021-05-27 12:41 Kristian G. Andersen open
    The important addition to that question that I think is often forgotten - "in what setting". I can believe that 617 is more transmissible than 117 in certain settings (high natural immunity, high one-shot immunity, mostly), but in a naive population, is it more fit? Not so sure about that.
  8. 2021-05-27 12:45 Kristian G. Andersen open
    And it's worth pointing out that this is strictly an academic question, not a public health one - it's clear 617 is aproblem and we need to act, but that was clear weeks ago.
  9. 2021-05-27 13:06 Andrew Rambaut open
    Just discussing that. My personal hunch has been that B117 is adapted to strong NPI by being more transmissible early but for shorter (causing more damage and thus severity). Make the most of limited number of contacts. 617.2may have a longer pre-symptom period making it better in a more free-for-all environment (i.e., unfortunate timing asUK restrictions have lifted).

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