Chat message
Slack / Private Message Drop, p.764 [SLACK_000978] · slack_pm:msg:07998
Page text: p.764 · original PDF
- Date
- 2021-05-09 07:51
- Type
- chat message · slack
- recipient
- Kristian G. Andersen, Edward C. Holmes, Andrew Rambaut
- speaker
- Robert F. Garry
Recipients on this medium are inferred from channel membership, not per-message addressing.
That would be good. Hit her hard - gloves off! We cut some of the stuff Angie alluded to from Holmes 2020
(virological): "Based on a lower substitution rate for SARS-CoV-2 compared to the earliest isolates of SARS-CoV,Zhan, Davidson and Chan (2020) concluded that it was possible that SARS-CoV-2 had been pre-adapted for human growth in the laboratory. However, there has also been limited sampling early in the COVID-19 outbreak, precludingobservation of an early period of increased generation of variants followed by purifying selection (Park et al., 2015).It is not unusual for related viruses to have substitution rates that vary in the range seen by Zhan, Davidson and Chan (2020). For example: the rates of nucleotide substitution in the four serotypes of DENV--range from 4.55 ×10^-4 (DEN-1) to 11.58 × 10^-4 (DEN-3) substitutions per site, per year (Twidy, Holmes, Rambaut, 2003)."