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Slack / Private Message Drop, p.739 [SLACK_000953] · slack_pm:msg:07735

Page text: p.739 · original PDF

Date
2021-04-30 12:06
Type
chat message · slack
recipient
Robert F. Garry, Edward C. Holmes, Andrew Rambaut
speaker
Kristian G. Andersen

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Yeah, there's a massive lack of sequencing in-country. We also picked up B.1.617.2 yesterday - I think a lot of travel cases with that one (and B.1.1.7 - but may skew towards 617)

In context

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  1. 2021-04-30 11:40 Kristian G. Andersen open
    @Andrew Rambaut - do any of you have a read on what's going on in India? I see a lot of anecdotal 'data' of vaccinated people (doctors) getting infected, but I can't get a read on how reliable that data is. With the crop ofvaccines in India and B.1.617 I'm concerned, but I don't really know what to make of it - people are _much_ too quick to dismiss both the variant and breakthroughs though (with no data).
  2. 2021-04-30 12:02 Andrew Rambaut open
    I am not sure I do know what is going on. The biggest rise we have seen in imports from India is in the B.1.617.2lineage (which has 484E). But this isn't much in the Indian sequencing. I assume that is because their sampling isreally skewed (probably geographically).
  3. 2021-04-30 12:06 Kristian G. Andersen
    Yeah, there's a massive lack of sequencing in-country. We also picked up B.1.617.2 yesterday - I think a lot of travel cases with that one (and B.1.1.7 - but may skew towards 617)
  4. 2021-04-30 12:06 Kristian G. Andersen open
    And more so than I'd expect.
  5. 2021-04-30 12:37 Andrew Rambaut open
    yes - we are getting almost all B.1.617.2 in travel cases - I assume it is big in a city that is not covered by sampling but has lots of international travel (Mumbai?)
  6. 2021-04-30 12:38 Andrew Rambaut open
    But it shows the 'double mutant' is not what matters. It could be the P681R of course.
  7. 2021-04-30 12:41 Kristian G. Andersen open
    P681R for sure - for transmissibility. However, T19R, L452R, T478K, and possibly D950N likely adding significantlyto immune 'phenotype'.

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