Chat message

Slack / Private Message Drop, p.719 [SLACK_000933] · slack_pm:msg:07551

Date: 2021-04-20 09:26
Type: chat message · slack
recipient: Kristian G. Andersen, Edward C. Holmes, Andrew Rambaut
speaker: Robert F. Garry

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Here's a leopard getting infected it seems with B117: Virus name: hCoV-19/leopard/Czech Republic/4102-5/2021 Accession ID: EPI_ISL_1497614 SC2 is adapting to humans, but seemingly not "giving up on" being pan-tropic.

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2021-04-20 09:26 Robert F. Garry

Here's a leopard getting infected it seems with B117: Virus name: hCoV-19/leopard/Czech Republic/4102-5/2021 Accession ID: EPI_ISL_1497614 SC2 is adapting to humans, but seemingly not "giving up on" being pan-tropic.
2021-04-20 10:07 Kristian G. Andersen open

SLACK_000934 Non-specifically increasing affinity for mammalian ACE2 receptor...
2021-04-20 10:07 Robert F. Garry open

Perhaps - curious to see the genomes of the otter SC2s - I'm guessing N501T or Y453F. Maybe some changes in NTD as well.
2021-04-20 10:07 Andrew Rambaut open

"Lam a reporter at Science and my colleague Martin Enserink suggested I reach out to you. I am trying to evaluatethe importance of this new preprint: https:/Awww.biorxiv.org/content/10.1101/2021.04.16.440141v1 ?rss=1%22 andam hoping that you can take a quick look at it and give me your reaction to it. Toward that end, I've included some questions below, but we can also talk by zoom if that's more convenient.Please let me know right away that this message has reached you and how you can help. Many thanks. Stay safe, and sane.Elizabeth PennisiScienceDo I call you and evolutionary biologist? If not, then what? What impresses you about this paper and why? What is the most important new insight it provides on the origin of this variant? How strong is the evidence that this variant may have arisen in dogs? Are you convinced? Why or why not? What are your current thoughts about the origin of this variant? What are the biomedical implications of this paper? Any other thoughts? Thanks again,LizOne for you Kristian - animal reservoir. However quick look suggests total balloux. Seems they have mutationsaccumulating backwards in time.
2021-04-20 10:07 Kristian G. Andersen open

Yeah, she emailed me too - looks like complete bs.

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