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Slack / Private Message Drop, p.562 [SLACK_000776] · slack_pm:msg:05871

Date: 2021-03-02 18:50
Type: chat message · slack
recipient: Robert F. Garry, Edward C. Holmes, Andrew Rambaut
speaker: Kristian G. Andersen

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Yeah, interesting model here: http://biosig.unimelb.edu.au/covid3d/mutation/QHD43416/ACE2_BOAT/L455F/A. But I feel that L452R mutation must mess around with this whole interface, so lord knows what L455F does on top. Probably all just random, but pretty interesting to see 2/6 key binding residues hit in a single virus (and acharacteristic deletion - so probably some funky infection).

Links shared

other http://biosig.unimelb.edu.au/covid3d/mutation/QHD43416/ACE2_BOAT/L455F/A

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2021-03-02 18:13 Edward C. Holmes open

Can you tell me what the Australian sequences are? I'll look into it. No way that L455F will have been studied here.
2021-03-02 18:33 Kristian G. Andersen open

I can't... We're unfortunately not allowed to pull GISAID IDs... I can see UK has a few of the double mutants too. https://outbreak.info/situation-reports?pango&muts=S%3AN501Y&muts=S%3AL455F
2021-03-02 18:45 Edward C. Holmes open

Ok, I'll ask about it.
2021-03-02 18:47 Robert F. Garry open

I'll look - any change to an aromatic amino acid could potentially set up a stronger binding.
2021-03-02 18:50 Kristian G. Andersen

Yeah, interesting model here: http://biosig.unimelb.edu.au/covid3d/mutation/QHD43416/ACE2_BOAT/L455F/A. But I feel that L452R mutation must mess around with this whole interface, so lord knows what L455F does on top. Probably all just random, but pretty interesting to see 2/6 key binding residues hit in a single virus (and acharacteristic deletion - so probably some funky infection).

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