Chat message

Slack / Private Message Drop, p.471 [SLACK_000685] · slack_pm:msg:04892

Date: 2021-02-01 04:58
Type: chat message · slack
recipient: Kristian G. Andersen, Edward C. Holmes, Andrew Rambaut
speaker: Robert F. Garry
Topics: Furin cleavage site and molecular features Natural origin / zoonotic spillover

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This is really awesome - the thing that popped for me is the remarkable similarity of HA379 and GDpango in the Nterminus and NTD. Thereafter in the RBD totally different. It's a funhouse mirror of RaTG13, GX pangolin coronavirus and SARS-CoV-2 that share a similar indel structure and several common or similar sequences in the N-terminus and the NTD. Then there is the mind-blowing new indel with dicysteines in the HA363 group. I'm guessing a new short loop but need to look at the structure.

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2021-02-01 04:58 Robert F. Garry

This is really awesome - the thing that popped for me is the remarkable similarity of HA379 and GDpango in the Nterminus and NTD. Thereafter in the RBD totally different. It's a funhouse mirror of RaTG13, GX pangolin coronavirus and SARS-CoV-2 that share a similar indel structure and several common or similar sequences in the N-terminus and the NTD. Then there is the mind-blowing new indel with dicysteines in the HA363 group. I'm guessing a new short loop but need to look at the structure.
2021-02-01 04:59 Robert F. Garry open

@Kristian Andersen will notice new cysteine loop in the NTD, which is something that arose in one of his long patients.
2021-02-01 05:30 Robert F. Garry open

@Eddie Holmes The HA379 and RmYN02 similarity is after the NTD and into the RBD - INTERESTING! Before that HA379 is much closer to GD pango.

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