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Slack / Private Message Drop, p.449 [SLACK_000663] · slack_pm:msg:04646

Date: 2021-01-25 09:41
Type: chat message · slack
recipient: Kristian G. Andersen, Edward C. Holmes, Andrew Rambaut
speaker: Robert F. Garry

Recipients on this medium are inferred from channel membership, not per-message addressing.

If you show this to Erica or Andrew Ward - they want to jump on this I am certain. Consider that it's never (at least asfar as I can tell with a quick look) been shown for HIV. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2555952/"Sequence variability of Env among different HIV strains is notorious and in part explains why the humoral immune response against HIV-1 is inadequate in patients. *Amid the countless changes in surrounding residues, the cysteine residues are strictly conserved among all isolates of HIV-1 (Louwagie _et al._, 1995 ; Los Alamos HIV sequence database: http://hiv-web.lanl.gov).* This suggests that the antigenic shield of Env may vary, but that thedisulfide-bonded structure of Env and hence the basic architecture of the molecule is constant?

Links shared

gov https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2555952/
other http://hiv-web.lanl.gov).*

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2021-01-25 09:27 Kristian G. Andersen open

Wow, that's pretty wild @Robert Garry - that's why we keep you around :wink:. I have never thought to think of thisas a cysteine bridge, so lord knows what it does to the structure. For now, this virus remains inside the patient - wehaven't seen any transmissions. With the patients at Tulane, I see a bigger study building....
2021-01-25 09:41 Robert F. Garry

If you show this to Erica or Andrew Ward - they want to jump on this I am certain. Consider that it's never (at least asfar as I can tell with a quick look) been shown for HIV. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2555952/"Sequence variability of Env among different HIV strains is notorious and in part explains why the humoral immune response against HIV-1 is inadequate in patients. *Amid the countless changes in surrounding residues, the cysteine residues are strictly conserved among all isolates of HIV-1 (Louwagie _et al._, 1995 ; Los Alamos HIV sequence database: http://hiv-web.lanl.gov).* This suggests that the antigenic shield of Env may vary, but that thedisulfide-bonded structure of Env and hence the basic architecture of the molecule is constant?
2021-01-25 09:49 Robert F. Garry open

The new swab samples from the Tulane patient are coming your way TODAY. Yes a bigger study - these two likely others are probably already looking at structures of the new variants, but yours will really get their blood boiling.CDC declined to come and do any contact tracing, but did offer up some advice for quarantining the patient. Regeneron wants to give the patient a whopping dose of their drug, which will cure him or give rise to a B.1.351 like variant.

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