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Slack / Private Message Drop, p.447 [SLACK_000661] · slack_pm:msg:04629

Date: 2021-01-24 09:00
Type: chat message · slack
recipient: Kristian G. Andersen, Edward C. Holmes, Andrew Rambaut
speaker: Robert F. Garry

Recipients on this medium are inferred from channel membership, not per-message addressing.

https://virological.org/t/emergence-of-y453f-and-69-70hv-mutations-in-a-lymphoma-patient-with-long-term-covid-19/580 Of course other immunosuppressed patients like this one here.

Links shared

preprint https://virological.org/t/emergence-of-y453f-and-69-70hv-mutations-in-a-lymphoma-patient-with-long-term-covid-19/580

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2021-01-24 08:29 Robert F. Garry open

Similar picture here.
2021-01-24 08:48 Robert F. Garry open

This patient in the Cell case study[!] is a bit more like the first NEJM patient. Some Mutations persist, others wink in,wink out. [shared file(s): image.png]
2021-01-24 08:49 Robert F. Garry open

Unfortunately no earlier sequence than from day 45, so don't know the baseline sequence.
2021-01-24 08:54 Robert F. Garry open

They also use the Q word [yikes], which perhaps suggests a teaching opportunity re viral population genetics.
2021-01-24 09:00 Robert F. Garry

https://virological.org/t/emergence-of-y453f-and-69-70hv-mutations-in-a-lymphoma-patient-with-long-term-covid-19/580 Of course other immunosuppressed patients like this one here.
2021-01-24 09:10 Robert F. Garry open

https://www.medrxiv.org/content/10.1101/2020.12.05.20241927v3 "N501Y in Spike was transiently detected at day 55 and V157L in RdRp emerged. However, following convalescent plasma we observed large, dynamic virus population shifts, with the emergence of a dominant viral strain bearing D796H in S2 and **H69/**V70 in the S1N-terminal domain NTD of the Spike protein." Importantly, no SC2 antibodies until they infused convalescientplasma.

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