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Slack / Private Message Drop, p.424 [SLACK_000638] · slack_pm:msg:04380

Date: 2021-01-19 07:59
Type: chat message · slack
recipient: Kristian G. Andersen, Edward C. Holmes, Andrew Rambaut
speaker: Robert F. Garry

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!channel This alignment boils it down: Cell culture passage of a GX virus backfills the B1.1.7 like delH69V70. PangoGD has a single aa deletion in indel region 2. GD pango has a deletion in IR3 close to de145Y in B1.1.7. GDpago also has an Indel region 5 deletion and one of the pango Gxs has a IR6 deletion. As Tommy notes the cell culture backfill in IR2 by the vero passed Gx virus is important. He should write this up or we should bring him on tothe virological post.

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2021-01-19 07:59 Robert F. Garry

!channel This alignment boils it down: Cell culture passage of a GX virus backfills the B1.1.7 like delH69V70. PangoGD has a single aa deletion in indel region 2. GD pango has a deletion in IR3 close to de145Y in B1.1.7. GDpago also has an Indel region 5 deletion and one of the pango Gxs has a IR6 deletion. As Tommy notes the cell culture backfill in IR2 by the vero passed Gx virus is important. He should write this up or we should bring him on tothe virological post.
2021-01-19 08:00 Robert F. Garry open

!channel This alignment boils it down: Cell culture passage of a GX virus backfills the B1.1.7 like delH69V70. PangoGD has a single aa deletion in indel region 2. GD pango has a deletion in IR3 close to de145Y in B1.1.7. GDpago also has an Indel region 5 deletion and one of the pango Gxs has a IR6 deletion. As Tommy notes the cell culture backfill in IR2 by the vero passed Gx virus is important. He should write this up or we should bring him on tothe virological post. [shared file(s): image.png]

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