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Slack / Private Message Drop, p.397 [SLACK_000611] · slack_pm:msg:04096

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Yes, the deletions at 69/70 and 145 as well as the cell culture insertions as 214/5 and around the FCS and do bring the sequences back closer to bat.

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2021-01-14 10:12 Robert F. Garry open

better: [shared file(s): image.png]
2021-01-14 10:29 Kristian G. Andersen open

@Kristian Andersen The overlap is uncanny... Probably just totally random, but when we first discussed it we did say "let's see what happens in Brazil"... Probably nothing, but worth keeping this in the back of our minds - it is alittle peculiar.
2021-01-14 10:43 Kristian G. Andersen open

This is very cool - thanks Bob I need to take a closer look at this - the broader implication would suggest that these are very evolutionary active regions. Joel mentioned that SC2 has a lot of reversions back to "bat", which is quite peculiar. Totally unrelated, but can I just mention one gripe here - Apoorva Mandavilli at NYTimes is doing a friggin' terrible job with her reporting. Really frustrating she's now the main SC2 reporter at NYTimes - they used to do so well. TheAtlantic it is (which is totally fine with me!).
2021-01-14 10:57 Robert F. Garry open

Yes indeed thank you -someone needs to look closely - I seem to have missed L18F and picked the wrong B1.1.351 without it, but corrected here. L18F still very much fits the pattern. Indeed, these are the evolutionarily active regions. [shared file(s): image.png]
2021-01-14 11:03 Robert F. Garry

Yes, the deletions at 69/70 and 145 as well as the cell culture insertions as 214/5 and around the FCS and do bring the sequences back closer to bat.