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Slack / Private Message Drop, p.344 [SLACK_000558] · slack_pm:msg:03620

Date: 2020-12-28 11:10
Type: chat message · slack
recipient: Kristian G. Andersen, Edward C. Holmes, Andrew Rambaut
speaker: Robert F. Garry
Topics: Furin cleavage site and molecular features

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I guess the question of "epistasis" between RBD and FCS and/or nsp6 mutations arises, but in my mind is more likely that all enhance replication independently.

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Statement	Grade	Attribution	Stance
I guess the question of "epistasis" between RBD and FCS and/or nsp6 mutations arises, but in my mind is more likely that all enhance replication independently.	quoted / not their view	quoted_external sentence carries quotation marks	asserts

Statement

Grade

Attribution

Stance

I guess the question of "epistasis" between RBD and FCS and/or nsp6 mutations arises, but in my mind is more likely that all enhance replication independently.

quoted / not their view

quoted_external sentence carries quotation marks

asserts

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2020-12-28 11:10 Robert F. Garry

I guess the question of "epistasis" between RBD and FCS and/or nsp6 mutations arises, but in my mind is more likely that all enhance replication independently.
2020-12-28 11:22 Robert F. Garry open

In addition the the three human SC2 to animal transfers noted (mice, mink, ferrets) there have also been well-documented human to cat :scream_cat: transfers and as well as it seems humans to dogs. https://www.nature.com/articles/s41421-020-00210-9 This has apparently been more newsworthy in China and there is this nice publication from G Gao of a crystal structure of SC2 spike with catACE2. The nucleotide and protein database in PubMed is not working well today :rage: for whatever reason, but of the few cat SC2 sequencesit is said that there are not changes in the RBD of the SC2 in cats. This makes VERY good sense. The main contact residues for S: Q493 and N501, which seem to mediate species transfers, are identical in human and cat ACE2,H34, Y41/K353.

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