Chat message

Slack / Private Message Drop, p.151 · slack_pm:msg:01551

Date: 2020-08-30 22:51 (hour precision)
Type: chat message · slack
recipient: Kristian G. Andersen, Edward C. Holmes, Andrew Rambaut
speaker: Robert F. Garry

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Yes - jarring if it holds up. Perhaps not surprising - SOME people get colds over and over again [repertoire holes?] and we know immunity to CoVs is rather short-lived at least in some people. I'd really want to see sequence data inboth episodes for each patient. Too many people think they had COVID in November to January but really did not. Then there is the whole false-positive PCR thing - so a Ct in the high 30s or 40 might not be real per the NYT a few days ago. Yes - sequence confirmed in the first episode or may not be real. I'm also concerned about the mention ofsecondary" humoral responses. This is not evidence of reinfection. It seems to me that all of the humoral responsesto SARS-CoV-2 appear to be secondary (likely due to previous seasonal exposures). In the COVID patients we've looked at IgG comes up at the same time as IgM and IgA, like a secondary response. Several other papers show the same thing. Also what are the neut titers? If they are low as seems typical they might well not be protective. Also Iagree with Andrew - some weird selection bias?

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2020-08-30 22:51 Andrew Rambaut open

Are the genomes different? Could these be chronic infections?
2020-08-30 22:51 Andrew Rambaut open

I guess they are different given '_phylogenic'._
2020-08-30 22:51 Kristian G. Andersen open

Yup, different genomes so not relapse
2020-08-30 22:51 Andrew Rambaut open

How are the 273 patients selected. It seems implausible that in most parts of the world 6 out of 273 would even beexposed twice let alone infected.
2020-08-30 22:51 Robert F. Garry

Yes - jarring if it holds up. Perhaps not surprising - SOME people get colds over and over again [repertoire holes?] and we know immunity to CoVs is rather short-lived at least in some people. I'd really want to see sequence data inboth episodes for each patient. Too many people think they had COVID in November to January but really did not. Then there is the whole false-positive PCR thing - so a Ct in the high 30s or 40 might not be real per the NYT a few days ago. Yes - sequence confirmed in the first episode or may not be real. I'm also concerned about the mention ofsecondary" humoral responses. This is not evidence of reinfection. It seems to me that all of the humoral responsesto SARS-CoV-2 appear to be secondary (likely due to previous seasonal exposures). In the COVID patients we've looked at IgG comes up at the same time as IgM and IgA, like a secondary response. Several other papers show the same thing. Also what are the neut titers? If they are low as seems typical they might well not be protective. Also Iagree with Andrew - some weird selection bias?
2020-08-30 22:51 Andrew Rambaut open

Is the paper pre-printed?

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