Chat message

Slack / Private Message Drop, p.78 [SLACK_000292] · slack_pm:msg:00785

Date: 2020-06-13 10:31
Type: chat message · slack
recipient: Kristian G. Andersen, Robert F. Garry, Edward C. Holmes
speaker: Andrew Rambaut
Topics: Natural origin / zoonotic spillover

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Shows better how the pangolin distance is exactly the same in the variable as the rest of the CTD whereas RaTG13jumps out.

Extracted statements

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Statement	Grade	Attribution	Stance
Shows better how the pangolin distance is exactly the same in the variable as the rest of the CTD whereas RaTG13jumps out.	own voice, substantive	speaker_own	asserts

Statement

Grade

Attribution

Stance

Shows better how the pangolin distance is exactly the same in the variable as the rest of the CTD whereas RaTG13jumps out.

own voice, substantive

speaker_own

asserts

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2020-06-13 08:48 Robert F. Garry open

"time for an update review - there is lots of new stuff to think about.":beer:
2020-06-13 09:35 Andrew Rambaut open

Jotting down some of the new stuff: Bill's potential source of the furin site - perhaps could dig into that more. Looks like SARS-CoV-2 can infect and readily transmit in mink (in the Netherlands). https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2020.25.23.2001005#html_fulltext - some severe disease too. Infects cats. So broad host range. Look into that press-release about infecting fruit bats (and cats). Recombination of RBD variable loop out of RaTG13 rather than in to SARS-CoV-2 from pangolins. Large variety of pangolin viruses (these are illegally imported from SE Asia - so where are they getting them from). Seems to readily loose furin site in cell culture. Really odd mutation patterns with lots of C->T and A->T, much higher NSyn/Syn ratio than you would expect? RmYN02 being closer in ORF1ab but recombines out in the rest - tell us something but not sure what just yet. Deletions in the accessory genes - suggests ORF7 & 8 maybe don't have much function in humans - somebatty thing?
2020-06-13 10:08 Robert F. Garry open

Well done Kristian [to BBC] and Andrew [above}! Andrew's list is great - I don't see anything that points to active[cloning] or passive [cell or animal passage] lab manipulation however for balance we could put in some of Kristian's points above. [shared file(s): 220px-Leafy_Seadragon_on_Kangaroo_Island.jpg]
2020-06-13 10:24 Andrew Rambaut open

We just resubmitted our revised MS on the 'distal' origin. I added a new figure to supplementary on the variable loop recombination: [shared file(s): image.png]
2020-06-13 10:31 Andrew Rambaut

Shows better how the pangolin distance is exactly the same in the variable as the rest of the CTD whereas RaTG13jumps out.

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