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Slack / Private Message Drop, p.24 [SLACK_000238] · slack_pm:msg:00240

Date: 2020-05-13 13:57
Type: chat message · slack
mentioned: Edward C. Holmes
recipient: Robert F. Garry, Edward C. Holmes, Andrew Rambaut
speaker: Kristian G. Andersen

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@Eddie Holmes There's a little bit of activity in a few samples. A see a couple of samples where the P becomes L,'turning off' the O-linked glycans. There's also a single example from a human patient where the site is deleted - the full 12bp.Other than that, not much going on - I'll take a look at the synonymous changes.

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2020-05-13 13:57 Kristian G. Andersen

@Eddie Holmes There's a little bit of activity in a few samples. A see a couple of samples where the P becomes L,'turning off' the O-linked glycans. There's also a single example from a human patient where the site is deleted - the full 12bp.Other than that, not much going on - I'll take a look at the synonymous changes.
2020-05-13 14:34 Kristian G. Andersen open

@Eddie Holmes @Eddie Holmes - based on a brief glance, not much on the Syn level either - maybe a little less, meaning this is probably evolving neutrally(ish). Formal analyses would be interesting.
2020-05-13 14:36 Edward C. Holmes open

Thanks Bob. I'll take another look at Bill's post. I've met Prof King a number of times - she's certainly a 'character'.She has a plastic cover over her laptop keyboard that must have been there for 30 years...in shreds.
2020-05-13 14:57 Robert F. Garry open

Nice person - pretty sure that did not change - but not sure she ever got over the cultural shock that Austin in the70's was not the "Magic Kingdom." Somewhat obsessive about Mickey, Minnie and Donald.
2020-05-13 15:19 Edward C. Holmes open

Thanks. Would be interesting to do a more formal analysis to see if this insertion site is evolving in any way unusually. Sounds like it is under fairly strong selective constraints.

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