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UNCLASSIFIED UNCLASSIFIED Furthermore, the EcoHealth proposal states that a "vaccine approach lacks sufficient epitope coverage to protect against quasispecies of coronavirus."x Consequently, they were trying to make vaccines work by "targeted immune boosting via vaccine inoculators using chimeric polyvalent recombinant spike proteins."xi The nature of using a spike protein vaccine with one epitope against a spike protein vaccine with a quasispecies may explain the unusual (and potentially detrimental) antibody response amongst the vaccinated to the new COVID variants.xii Fundamentally, the knowledge the proposal provides signals that the risk of Antibody Dependent Enhancement (ADE) from vaccination should be evaluated with high priority, on top of the reality that single-epitope vaccines will have little effect against SARSr-CoV-WIV, as indicated in the proposal. The potential for SARSr-CoV-WIV to deattentuate requires immediate attention. Live vaccines have been found to deattentuate in the past. If this is the case with SARSr-CoV-WIV, then the mass vaccination campaign actually performs an accelerated gain-of-function for it. Since it is designed for bats off of a human-susceptible SARS-CoV, vaccinating humans against it actually gains its function back towards a more deattenuated human-susceptible form. Improving the SARSr-CoV-WIV spike protein to gain robustness against monoclonal vaccines is one of the steps of the DEFUSE program. The mechanism to improve the SARSr-CoV-WIV spike protein (other than direct engineering) is to challenge it against animals that have spike protein-only antibodies. The attenuated virus will either die or adapt its form to neutralize the spike protein-only antibodies. The intent was to perform this task against humanized mice and then "batified" mice. Instead, it was done with the world's population. SARSr-CoV-WIV is not meant to kill the bats, but to immunize them. This nature may explain its general harmlessness to most people, and its harmfulness to the old and comorbid, who are in general more susceptible to vaccine reactions. The asymptomatic nature is also explained by the bat vaccine-intention of its creators (a good vaccine does not generate symptoms). Such effects would be expected of an immature vaccine, or a vaccine being reverse engineered from a more virulent form into an attenuated form. The spike protein effect on ACE2 receptors exacerbates the harmfulness in accordance with age and comorbidity. The nature of SARSr-CoV-WIV's deattentuation will also indicate future virulence, though knowing its nature at last neutralizes the threat as effective treatments can be applied with confidence. 3. DRASTIC and other scientists will clean up my description of SARSrCoV-WIV's nature and progression within the DEFUSE program. This information is sufficient for an investigative report and more than enough to correct the existing pandemic strategy. Previously, the nation did not know itself, nor the adversary in the pandemic conflict. Now it knows both. The problem can be framed appropriately and specifically against a confirmed hypothesis. Limiting disease transmission can be dropped as the implied strategic end, as it is not the actual problem, For SHSGAC Use Only - SHSGAC_COVID_119th 011835